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Metabolomic Analysis Reveals Increased Aerobic Glycolysis and Amino Acid Deficit in a Cellular Model of Amyotrophic Lateral Sclerosis

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Title: Metabolomic Analysis Reveals Increased Aerobic Glycolysis and Amino Acid Deficit in a Cellular Model of Amyotrophic Lateral Sclerosis
Authors: Valbuena, GN
Rizzardini, M
Cimini, S
Siskos, AP
Bendotti, C
Cantoni, L
Keun, HC
Item Type: Journal Article
Issue Date: 12-May-2015
Date of Acceptance: 27-Mar-2015
URI: http://hdl.handle.net/10044/1/33943
DOI: http://dx.doi.org/10.1007/s12035-015-9165-7
ISSN: 1559-1182
Publisher: Springer Verlag
Start Page: 2222
End Page: 2240
Journal / Book Title: Molecular Neurobiology
Volume: 53
Issue: 4
Copyright Statement: © The Author(s) 2015. This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
Sponsor/Funder: Commission of the European Communities
Funder's Grant Number: 259867
Keywords: Science & Technology
Life Sciences & Biomedicine
Neurosciences
Neurosciences & Neurology
Amyotrophic lateral sclerosis
Amino acids
Glycolysis
Glutamine
Glutamate
Motor neuron
NSC-34
Serine
Cu/Zn superoxide dismutase
Pyruvate dehydrogenase kinase 1
INTEGRATED STRESS-RESPONSE
PYRUVATE-DEHYDROGENASE KINASE
OXIDATIVE STRESS
MOTOR-NEURONS
SPINAL-CORD
GLUCOSE-UTILIZATION
DISMUTASE 1
IN-VITRO
ALS
HYPOXIA
Neurology & Neurosurgery
1109 Neurosciences
1702 Cognitive Science
Publication Status: Published
Open Access location: http://link.springer.com/article/10.1007/s12035-015-9165-7
Appears in Collections:Division of Surgery
Division of Cancer



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