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HIV-tuberculosis-associated immune reconstitution inflammatory syndrome is characterized by Toll-like receptor and inflammasome signalling

Title: HIV-tuberculosis-associated immune reconstitution inflammatory syndrome is characterized by Toll-like receptor and inflammasome signalling
Authors: Lai, RPJ
Meintjes, G
Wilkinson, KA
Graham, CM
Marais, S
Van der Plas, H
Deffur, A
Schutz, C
Bloom, C
Munagala, I
Anguiano, E
Goliath, R
Maartens, G
Banchereau, J
Chaussabel, D
O'Garra, A
Wilkinson, RJ
Item Type: Journal Article
Issue Date: 24-Sep-2015
Date of Acceptance: 21-Aug-2015
URI: http://hdl.handle.net/10044/1/33888
DOI: http://dx.doi.org/10.1038/ncomms9451
ISSN: 2041-1723
Publisher: Nature Publishing Group
Journal / Book Title: Nature Communications
Volume: 6
Copyright Statement: This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
Sponsor/Funder: Wellcome Trust
Funder's Grant Number: 104803/Z/14/ZR
Keywords: Science & Technology
Multidisciplinary Sciences
Science & Technology - Other Topics
MYCOBACTERIUM-TUBERCULOSIS
INFECTED PATIENTS
ANTIRETROVIRAL THERAPY
NLRP3 INFLAMMASOME
INTERFERON-GAMMA
ACTIVATION
MACROPHAGES
INNATE
INTERLEUKIN-1
RESPONSES
Adult
Antiretroviral Therapy, Highly Active
Caspase 1
Caspases
Cytokines
Female
Gene Expression Profiling
HIV Infections
Humans
Immune Reconstitution Inflammatory Syndrome
Immunity, Innate
Inflammasomes
Inflammation Mediators
Interleukin-1
Leukocytes, Mononuclear
Male
Membrane Glycoproteins
Receptors, Immunologic
Receptors, Interleukin-1
Toll-Like Receptors
Tuberculosis
Young Adult
MD Multidisciplinary
Publication Status: Published
Article Number: 8451
Appears in Collections:National Heart and Lung Institute
Department of Medicine



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