Development of a cyclin-dependent kinase inhibitor devoid of ABC transporter-dependent drug resistance

Title: Development of a cyclin-dependent kinase inhibitor devoid of ABC transporter-dependent drug resistance
Authors: Kaliszczak, M
Patel, H
Kroll, SHB
Carroll, L
Smith, G
Delaney, S
Heathcote, DA
Bondke, A
Fuchter, MJ
Coombes, RC
Barrett, AGM
Ali, S
Aboagye, EO
Item Type: Journal Article
Issue Date: 26-Sep-2013
Date of Acceptance: 4-Sep-2003
URI: http://hdl.handle.net/10044/1/33463
DOI: http://dx.doi.org/10.1038/bjc.2013.584
ISSN: 1532-1827
Publisher: Cancer Research UK
Start Page: 2356
End Page: 2367
Journal / Book Title: British Journal of Cancer
Volume: 109
Issue: 9
Copyright Statement: From twelve months after its original publication, this work is licensed under the Creative Commons Attribution-NonCommercial-Share Alike 3.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-sa/3.0/
Sponsor/Funder: Cancer Research UK
Cancer Research UK
Cancer Research UK
Funder's Grant Number: C21484/A6944/A9520/G20971
C2536/A10337
C37/A12011
Keywords: Science & Technology
Life Sciences & Biomedicine
Oncology
ONCOLOGY
BREAST-CANCER CELLS
POSITRON-EMISSION-TOMOGRAPHY
PHASE-I TRIAL
P-GLYCOPROTEIN
MULTIDRUG-RESISTANCE
ANTITUMOR-ACTIVITY
R-ROSCOVITINE
MOLECULAR-MECHANISMS
GROWTH
POTENT
ATP-Binding Cassette Transporters
Animals
Apoptosis
Cell Cycle Checkpoints
Cell Division
Cell Line, Tumor
Cell Membrane Permeability
Cyclin D1
Cyclin-Dependent Kinases
Down-Regulation
Drug Resistance, Neoplasm
Female
G2 Phase
HCT116 Cells
Humans
MCF-7 Cells
Mice
Mice, Inbred BALB C
Mice, Nude
Myeloid Cell Leukemia Sequence 1 Protein
Neoplasm Proteins
P-Glycoprotein
P-Glycoproteins
Phosphorylation
Protein Kinase Inhibitors
Pyrimidines
Xenograft Model Antitumor Assays
Oncology & Carcinogenesis
1112 Oncology And Carcinogenesis
Publication Status: Published
Appears in Collections:Division of Surgery
Chemistry
Division of Cancer
Faculty of Medicine
Faculty of Natural Sciences



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