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IgA1 glycosylation is heritable in healthy twins

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Title: IgA1 glycosylation is heritable in healthy twins
Authors: Lomax-Browne, HJ
Visconti, A
Pusey, CD
Spector, TD
Pickering, MC
Falchi, M
Cook, HT
Item Type: Journal Article
Abstract: IgA Nephropathy (IgAN) is the most common form of primary glomerulonephritis and an important cause of kidney failure. Characteristically, IgAN patients have increased serum levels of under-galactosylated IgA1 (gd-IgA1). We assessed the degree to which serum gd-IgA1 levels are genetically determined in healthy individuals. Serum IgA and gd-IgA1 level were determined by ELISA in a sample of 148 healthy female twins including 27 monozygotic and 47 dizygotic pairs. Using the classical twin model, the heritability of serum gd-IgA1 and IgA levels were 80% (95% CI: 66-89%) and 46% (95% CI: 15-69%) respectively. These data indicate that serum gd-IgA1 levels are highly heritable. Elucidating the genetic basis of this heritability will be important in understanding the pathogenesis of IgAN.
Issue Date: 16-Jun-2016
Date of Acceptance: 16-May-2016
URI: http://hdl.handle.net/10044/1/33245
DOI: https://dx.doi.org/10.1681/ASN.2016020184
ISSN: 1533-3450
Publisher: American Society of Nephrology
Start Page: 64
End Page: 68
Journal / Book Title: Journal of the American Society of Nephrology
Volume: 28
Issue: 1
Copyright Statement: © 2016 by the American Society of Nephrology
Sponsor/Funder: National Institute for Health Research
King's College London
Funder's Grant Number: NF-SI-0611-10055
MR/K01353X/1
Keywords: Science & Technology
Life Sciences & Biomedicine
Urology & Nephrology
GENOME-WIDE ASSOCIATION
GALACTOSE-DEFICIENT IGA1
SUSCEPTIBILITY LOCI
RENAL-TRANSPLANTATION
IMMUNE-COMPLEXES
SWEDISH TWINS
HAN CHINESE
NEPHROPATHY
PATHOGENESIS
ANTIBODIES
IgA nephropathy
gd-IgA1
glycosylation
human genetics
Adult
Aged
Aged, 80 and over
Diseases in Twins
Female
Glomerulonephritis, IGA
Glycosylation
Humans
Immunoglobulin A
Middle Aged
1103 Clinical Sciences
Publication Status: Published
Appears in Collections:Department of Medicine
Faculty of Medicine



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