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Aortic stiffness is related to the ischemic brain injury biomarker N-methyl-D-aspartate receptor antibody levels in aortic valve replacement

Title: Aortic stiffness is related to the ischemic brain injury biomarker N-methyl-D-aspartate receptor antibody levels in aortic valve replacement
Authors: Kidher, E
Patel, VM
Nihoyannopoulos, P
Anderson, JR
Chukwuemeka, A
Francis, DP
Ashrafian, H
Athanasiou, T
Item Type: Journal Article
Abstract: Background. Aortic stiffness changes the flow pattern of circulating blood causing microvascular damage to different end-organ tissues, such as brain cells. The relationship between aortic stiffness measured by pulse wave velocity (PWV) and serum ischemic brain injury biomarker N-methyl-D-aspartate receptor antibody (NR2Ab) levels in aortic valve replacement has not been assessed. Methods. Patients undergoing aortic valve replacement (AVR) for aortic stenosis (AS) had their PWV and NR2Ab serum levels measured preoperatively. We analyzed PWV and NR2Ab in two ways: (1) as continuous variables using the actual value and (2) as dichotomous variables (PWV-norm and PWV-high groups) and (NR2Ab-low and NR2Ab-high groups). Results. Fifty-six patients (71 ± 8.4 years) were included in this study. The NR2Ab level (ng/mL) was significantly higher in the PWV-high group (n = 21) than in PWV-norm group (n = 35; median 1.8 ± 1.2 versus 1.2 ± 0.7, resp., P = 0.003). NR2Ab level was positively associated with PWV and negatively associated with male gender. Multiple regression revealed PWV independently related to NR2Ab level, and PWV cut-off was associated with a 7.23 times increase in the likelihood of having high NR2Ab (>1.8 ng/mL). Conclusion. Higher PWV in patients with surgical aortic stenosis is associated with higher levels of the ischemic brain biomarker NR2Ab.
Issue Date: 26-Jun-2014
Date of Acceptance: 15-Jun-2014
URI: http://hdl.handle.net/10044/1/33204
DOI: http://dx.doi.org/10.1155/2014/970793
ISSN: 2090-1860
Publisher: Hindawi Publishing Corporation
Journal / Book Title: Neurology Research International
Volume: 2014
Copyright Statement: © 2014 Emaddin Kidher et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Sponsor/Funder: British Heart Foundation
Funder's Grant Number: FS/10/38/28268
Publication Status: Published
Article Number: 970793
Appears in Collections:Division of Surgery
National Heart and Lung Institute
Faculty of Medicine



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