Automated identification and measurement of Hematopoietic Stem Cells in 3D Intravital Microscopy Data

File Description SizeFormat 
51404.pdfPublished version17.07 MBAdobe PDFView/Open
Title: Automated identification and measurement of Hematopoietic Stem Cells in 3D Intravital Microscopy Data
Authors: Khorshed, RA
Lo Celso, C
Item Type: Chapter
Abstract: Image analysis and quantification of Haematopoietic stem cells (HSCs) position within their surrounding microenvironment in the bone marrow is a fast growing area of research, as it holds the key to understanding the dynamics of HSC-niche interactions and their multiple implications in normal tissue development and in response to various stress events. However, this area of research is very challenging due to the complex cellular structure of such images. Therefore, automated image analysis tools are required to simplify the biological interpretation of 3D HSC microenvironment images. In this chapter, we describe how 3D intravital microscopy data can be visualised and analysed using a computational method that allows the automated quantification of HSC position relative to surrounding niche components.
Editors: Stanciu, SG
Issue Date: 21-Sep-2016
URI: http://hdl.handle.net/10044/1/33180
DOI: http://dx.doi.org/10.5772/64089
ISBN: 978-953-51-2578-5
Publisher: InTech
Journal / Book Title: Microscopy and Analysis
Copyright Statement: © The Author(s). CC BY 3.0 license.
Sponsor/Funder: Biotechnology and Biological Sciences Research Council (BBSRC)
Commission of the European Communities
Biotechnology and Biological Sciences Research Council (BBSRC)
Funder's Grant Number: BB/K021168/1
337066
BB/L023776/1
Publication Status: Published
Article Number: 8
Appears in Collections:Faculty of Natural Sciences



Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Creative Commonsx