Linking e-health records, patient-reported symptoms and environmental exposure data to characterise and model COPD exacerbations: protocol for the COPE study

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Title: Linking e-health records, patient-reported symptoms and environmental exposure data to characterise and model COPD exacerbations: protocol for the COPE study
Authors: Moore, EA
Chatzidiakou, L
Jones, RL
Smeeth, L
Beevers, S
Kelly, FJ
Quint, JK
Barratt, B
Item Type: Journal Article
Abstract: Introduction: Relationships between exacerbations of chronic obstructive pulmonary disease (COPD) and environmental factors such as temperature, humidity and air pollution are not well characterised, due, in part, to oversimplification in the assignment of exposure estimates to individuals and populations. New developments in miniature environmental sensors mean that patients can now carry a personal air quality monitor for long periods of time as they go about their daily lives. This creates the potential for capturing a direct link between individual activities, environmental exposures and the health of COPD patients. Direct associations then have the potential to be scaled up to population levels and tested using advanced human exposure models linked to electronic health records (EHRs). Methods and analysis: This study has five stages: 1) development and deployment of personal air monitors (PAM); 2) recruitment and monitoring of a cohort of 160 COPD patients for up to six months with recruitment of participants through the Clinical Practice Research Datalink (CPRD); 3) statistical associations between personal exposure with COPD related health outcomes; 4) validation of a time-activity exposure model; and 5) development of a COPD prediction model for London. Ethics and dissemination: The research ethics committee for Camden & Islington has provided ethical approval for the conduct of the study. Approval has also been granted by NHS Research & Development and the Independent Scientific Advisory Committee. The results of the study will be disseminated through appropriate conference presentations and peer reviewed journals.
Issue Date: 13-Jul-2016
Date of Acceptance: 24-May-2016
ISSN: 2044-6055
Publisher: BMJ Publishing Group
Journal / Book Title: BMJ Open
Volume: 6
Issue: 7
Copyright Statement: This is an Open Access article distributed in accordance with the terms of the Creative Commons Attribution (CC BY 4.0) license, which permits others to distribute, remix, adapt and build upon this work, for commercial use, provided the original work is properly cited. See:
Sponsor/Funder: Medical Research Council (MRC)
Funder's Grant Number: JVABADR
Publication Status: Published
Article Number: e011330
Appears in Collections:National Heart and Lung Institute
Faculty of Medicine

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