The global burden of viral hepatitis from 1990 to 2013: findings from the Global Burden of Disease Study 2013

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Title: The global burden of viral hepatitis from 1990 to 2013: findings from the Global Burden of Disease Study 2013
Authors: Stanaway, JD
Flaxman, AD
Naghavi, M
Fitzmaurice, C
Vos, T
Abubakar, I
Abu-Raddad, LJ
Assadi, R
Bhala, N
Cowie, B
Forouzanfour, MH
Groeger, J
Mohd Hanafiah, K
Jacobsen, KH
James, SL
MacLachlan, J
Malekzadeh, R
Martin, NK
Mokdad, AA
Mokdad, AH
Murray, CJL
Plass, D
Rana, S
Rein, DB
Richardus, JH
Sanabria, J
Saylan, M
Shahraz, S
So, S
Vlassov, VV
Weiderpass, E
Wiersma, ST
Younis, M
Yu, C
El Sayed Zaki, M
Cooke, GS
Item Type: Journal Article
Abstract: Background: With recent improvements in vaccines and treatments against viral hepatitis, a better understanding of the burden of viral hepatitis is needed to inform global intervention strategies. We present estimates from the Global Burden of Disease (GBD) Study of morbidity and mortality for acute viral hepatitis, and for cirrhosis and liver cancer due to viral hepatitis by age, sex and country for 1990 through 2013. Methods: Mortality was estimated using natural history models for acute hepatitis and GBD’s cause-of-death ensemble model for cirrhosis and liver cancer. We estimated disease prevalence, and liver cancer and cirrhosis aetiologies via meta-regression. Disability adjusted life-years (DALYs) were calculated as the sum of years of life lost (YLLs) and years lived with disability (YLDs). Findings: Between 1990 and 2013, viral hepatitis deaths increased from 0·90 million (95% uncertainty interval 0·86 – 0·94) to 1·45 million (1·38–1·54); YLLs increased from 31·0 million (29·6–32·6) to 41·6 million (39·1–44·7); YLDs, from 0·65 million (0·45–0·89) to 0·87 million (0·61–1·18); and DALYs, from 31·7 million (30·2– 33·3) to 42·5 million (39·9–45·6). In 2013, viral hepatitis was the 7th leading cause of death globally. Interpretation: Viral hepatitis is a leading cause of death and disability worldwide. Unlike most communicable diseases, between 1990 and 2013, viral hepatitis has increased in terms of both absolute burden and its relative rank.
Issue Date: 7-Jul-2016
Date of Acceptance: 15-Apr-2016
ISSN: 0099-5355
Publisher: Elsevier
Start Page: 1081
End Page: 1088
Journal / Book Title: The Lancet
Volume: 388
Issue: 10049
Copyright Statement: © 2016 Elsevier. Licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
Keywords: General & Internal Medicine
11 Medical And Health Sciences
Publication Status: Published
Appears in Collections:Department of Medicine
Faculty of Medicine

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