Quantitative magnetic resonance imaging in patients with cirrhosis: a cross-sectional study.

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Title: Quantitative magnetic resonance imaging in patients with cirrhosis: a cross-sectional study.
Authors: Grover, VP
Crossey, MM
Fitzpatrick, JA
Saxby, BK
Shaw, R
Waldman, AD
Morgan, MY
Taylor-Robinson, SD
Item Type: Journal Article
Abstract: Cerebral magnetic resonance imaging was undertaken, at 3 Tesla field strength, employing magnetization transfer (MT) and diffusion-weighted imaging (DWI) sequences, in 26 patients with well-compensated cirrhosis, free of overt hepatic encephalopathy. Results were compared to those from 18 aged-matched healthy volunteers. Cerebral magnetization transfer ratios (MTR) were reduced in the frontal white matter, caudate, putamen and globus pallidus in patients with cirrhosis, compared to healthy controls, while the apparent diffusion coefficients (ADC) on DWI were significantly increased in the genu and body of the corpus callosum. An association between previous excessive alcohol consumption and both MTR and ADCs was noted, but this association was lost when controls were exercised for the severity of liver disease and psychometric impairment on multivariate analysis. Eight (31 %) of the 26 patients had impaired psychometric performance consistent with a diagnosis of minimal hepatic encephalopathy. No statistically significant difference in regional cerebral MTRs or ADCs was found in relation to neuropsychiatric status, although there was a trend towards lower MTRs in patients with impaired psychometric performance. The alterations in MTR and ADC in the patients with functionally compensated cirrhosis are compatible with theories governing the genesis of hepatic encephalopathy, including changes in astrocyte membrane permeability, with subsequent redistribution of macromolecules.
Issue Date: 8-Aug-2015
Date of Acceptance: 26-Jul-2015
URI: http://hdl.handle.net/10044/1/32623
DOI: https://dx.doi.org/10.1007/s11011-015-9716-7
ISSN: 1573-7365
Publisher: Springer Verlag (Germany)
Start Page: 1315
End Page: 1325
Journal / Book Title: Metabolic Brain Disease
Volume: 31
Issue: 6
Copyright Statement: © Springer Science+Business Media New York 2015. The final publication is available at Springer via http://dx.doi.org/10.1007/s11011-015-9716-7
Sponsor/Funder: Imperial College Trust
Royal College of Physicians
Imperial College Healthcare Charity
Friends of Hammersmith Hospital
Imperial College Healthcare NHS Trust- BRC Funding
Funder's Grant Number: PC2929 01/06/2002
BUPA FELLOWSHIP 2004
None given
None
RDA15 79560
Keywords: Apparent diffusion coefficients
Diffusion-weighted imaging
Hepatic encephalopathy
Magnetic resonance imaging
Magnetization transfer ratios
Neurology & Neurosurgery
1103 Clinical Sciences
1109 Neurosciences
Publication Status: Published
Appears in Collections:Division of Surgery
Department of Medicine
Faculty of Medicine



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