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Drugs for airway disease

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Title: Drugs for airway disease
Authors: Bonini, M
Usmani, OS
Item Type: Journal Article
Abstract: © 2016 Elsevier Ltd. All rights reserved.Asthma is a heterogeneous disease characterized by chronic airway inflammation and variable expiratory airflow limitation. It affects 5-15% of people worldwide and shows an increasing prevalence over the last decade. The treatment of asthma is well established in current guidelines, with the aim of achieving optimal disease control and preventing acute exacerbations using a stepwise medication approach. Drugs are commonly divided into relievers, which quickly alleviate airway obstruction, and controllers, which suppress the pathophysiology and provide long-term symptom control. β2-Adrenoreceptor agonists are the most effective therapy for reversing bronchial obstruction. Inhaled corticosteroids are recommended as first-line controller therapy for persistent asthma. Acute exacerbations often require systemic corticosteroids. Muscarinic antagonists, methylxanthines, anti-leukotrienes, cromones and macrolides also play a key role in disease management. The use of biological agents has recently received increasing attention, prompting a drive for a so-called precision-based medicine approach, particularly in more severe disease. The only biological drug currently licensed in Europe is the anti-IgE monoclonal antibody omalizumab. Several other antibodies and targeted molecules are under advanced development and are expected to be available on prescription soon, although they will be expensive.
Issue Date: 1-Apr-2016
Date of Acceptance: 1-Jan-2016
URI: http://hdl.handle.net/10044/1/32164
DOI: https://dx.doi.org/10.1016/j.mpmed.2016.02.015
ISSN: 1357-3039
Publisher: Elsevier
Start Page: 271
End Page: 280
Journal / Book Title: Medicine (United Kingdom)
Volume: 44
Issue: 5
Copyright Statement: © 2016, Elsevier. Licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International http://creativecommons.org/licenses/by-nc-nd/4.0/
Keywords: Arthritis & Rheumatology
Publication Status: Published
Appears in Collections:National Heart and Lung Institute
Airway Disease
Faculty of Medicine



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