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Consensus statement on research definitions for drug-resistant tuberculosis in children

Title: Consensus statement on research definitions for drug-resistant tuberculosis in children
Authors: Seddon, JA
Perez-Velez, CM
Schaaf, HS
Furin, JJ
Marais, BJ
Tebruegge, M
Detjen, A
Hesseling, AC
Shah, S
Adams, LV
Starke, JR
Swaminathan, S
Becerra, MC
Sentinel Project on Pediatric Drug-Resistant Tuberculosis
Item Type: Journal Article
Abstract: Few children with drug-resistant (DR) tuberculosis (TB) are identified, diagnosed, and given an appropriate treatment. The few studies that have described this vulnerable population have used inconsistent definitions. TheWorld Health Organization (WHO) definitions used for adults with DR-TB and for children with drug-susceptible TB are not always appropriate for children with DR-TB. The Sentinel Project on Pediatric Drug-Resistant Tuberculosis was formed in 2011 as a network of experts and stakeholders in childhood DRTB. An early priority was to establish standardized definitions for key parameters in order to facilitate study comparisons and the development of an evidence base to guide future clinical management. This consensus statement proposes standardized definitions to be used in research. In particular, it suggests consistent terminology, as well as definitions for measures of exposure, drug resistance testing, previous episodes and treatment, certainty of diagnosis, site and severity of disease, adverse events, and treatment outcome. © The Author 2013. Published by Oxford University Press on behalf of the Pediatric Infectious Diseases Society.
Issue Date: 10-Apr-2013
Date of Acceptance: 7-Feb-2013
URI: http://hdl.handle.net/10044/1/31661
DOI: http://dx.doi.org/10.1093/jpids/pit012
ISSN: 2048-7207
Publisher: Oxford University Press (OUP)
Start Page: 100
End Page: 109
Journal / Book Title: Journal of the Pediatric Infectious Diseases Society
Volume: 2
Issue: 2
Copyright Statement: © The Author 2013. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by-nc/3.0/), which permits non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Keywords: Children
Consensus
Definition
Drug-Resistance
Pediatric
Tuberculosis
Sentinel Project on Pediatric Drug-Resistant Tuberculosis
Publication Status: Published
Appears in Collections:Department of Medicine
Faculty of Medicine



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