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Diabetes in pregnancy and infant adiposity: systematic review and meta-analysis

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Title: Diabetes in pregnancy and infant adiposity: systematic review and meta-analysis
Authors: Logan, K
Gale, C
Hyde, M
Santhakumaran, S
Modi, N
Item Type: Journal Article
Abstract: Objective: Maternal glycaemia and anthropometry-derived newborn adiposity are strongly correlated. The children of mothers with diabetes are at greater risk of adverse metabolic health, and increased adiposity is a plausible mediator. We undertook a systematic review and meta-analysis to compare adiposity in infants of mothers with (IDM) and without diabetes (NIDM). Design: We identified observational studies reporting adiposity in IDM and NIDM. We searched references, traced forward citations and contacted authors for additional data. We considered all body composition techniques and compared fat mass, fat-free mass, body fat % and skinfold thickness. We used random effects meta-analyses and performed subgroup analyses by maternal diabetes type (type 1, type 2, gestational) and infant sex. We examined the influence of pre-pregnancy BMI and conducted sensitivity analyses. Results: We included data from 35 papers and over 24,000 infants. IDM have greater fat mass than NIDM (mean difference [95% CI]); 83g [49, 117]. Fat mass is greater in infants of mothers with gestational diabetes; 62g [29, 94] and type 1 diabetes; 268g [139, 397]. Insufficient studies reported data for type 2 diabetes separately. Compared with NIDM, fat mass was greater in IDM boys; 87g [30, 145], but not significantly different in IDM girls; 42g [- 33, 116]. There was no attenuation after adjustment for maternal BMI. Conclusions: IDM have significantly greater adiposity in comparison to NIDM. These findings are justification for studies to determine whether measures to reduce infant adiposity will improve later health.
Issue Date: 26-May-2016
Date of Acceptance: 25-Apr-2016
URI: http://hdl.handle.net/10044/1/31559
DOI: https://dx.doi.org/10.1136/archdischild-2015-309750
ISSN: 1468-2052
Publisher: BMJ Publishing Group
Start Page: F65
End Page: F72
Journal / Book Title: Archives of Disease in Childhood-Fetal and Neonatal Edition
Volume: 102
Copyright Statement: © 2016 The Authors. Published by the BMJ Publishing Group Limited. This is an Open Access article distributed in accordance with the terms of the Creative Commons Attribution (CC BY 4.0) license, which permits others to distribute, remix, adapt and build upon this work, for commercial use, provided the original work is properly cited. See: http://creativecommons.org/licenses/by/4.0/
Sponsor/Funder: Action Medical Research
The Academy of Medical Sciences
Funder's Grant Number: GN2008
N/A
Keywords: Science & Technology
Life Sciences & Biomedicine
Pediatrics
GESTATIONAL-AGE INFANTS
CARDIOVASCULAR RISK-FACTORS
BODY-COMPOSITION
GLUCOSE-TOLERANCE
CORD BLOOD
INTRAUTERINE EXPOSURE
MATERNAL GLUCOSE
INDIAN CHILDREN
BIRTH-WEIGHT
FAT MASS
Endocrinology
Neonatology
Obesity
Outcomes research
Adiposity
Birth Weight
Body Mass Index
Female
Humans
Infant, Newborn
Pregnancy
Pregnancy in Diabetics
Risk Factors
1114 Paediatrics And Reproductive Medicine
Publication Status: Published
Open Access location: http://fn.bmj.com/content/early/2016/05/26/archdischild-2015-309750.full
Appears in Collections:Department of Medicine
Faculty of Medicine
Epidemiology, Public Health and Primary Care



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