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Glucopyranosyl lipid A adjuvant significantly enhances HIV specific T and B cell responses elicited by a DNA-MVA-protein vaccine regimen

Title: Glucopyranosyl lipid A adjuvant significantly enhances HIV specific T and B cell responses elicited by a DNA-MVA-protein vaccine regimen
Authors: McKay, PF
Cope, AV
Mann, JFS
Joseph, S
Esteban, M
Tatoud, R
Carter, D
Reed, SG
Weber, J
Shattock, RJ
Item Type: Journal Article
Issue Date: 23-Jan-2014
Date of Acceptance: 18-Nov-2013
URI: http://hdl.handle.net/10044/1/31321
DOI: http://dx.doi.org/10.1371/journal.pone.0084707
ISSN: 1932-6203
Publisher: Public Library of Science
Journal / Book Title: PLOS One
Volume: 9
Issue: 1
Copyright Statement: © 2014 McKay et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Sponsor/Funder: Medical Research Council (MRC)
Funder's Grant Number: G1001784
Keywords: Science & Technology
Multidisciplinary Sciences
Science & Technology - Other Topics
MULTIDISCIPLINARY SCIENCES
IMMUNODEFICIENCY-VIRUS TYPE-1
HUMAN DENDRITIC CELLS
IMMUNE-RESPONSES
CLADE-C
NEUTRALIZING ANTIBODIES
LYMPHOCYTE RESPONSES
GENETIC-VARIATION
RHESUS-MONKEYS
GAG
IMMUNOGENICITY
AIDS Vaccines
Adjuvants, Immunologic
Animals
Antibodies, Viral
B-Lymphocytes
Cells, Cultured
Cytokines
Female
HIV Infections
Humans
Immunoglobulin A
Immunoglobulin G
Lipid A
Male
Mice
Mice, Inbred BALB C
Plasmids
Rabbits
Spleen
T-Lymphocytes
Vaccination
Vaccine Potency
Vaccines, DNA
Viral Vaccines
env Gene Products, Human Immunodeficiency Virus
General Science & Technology
MD Multidisciplinary
Publication Status: Published
Article Number: e84707
Appears in Collections:Department of Medicine
Faculty of Medicine



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