Modeling platinum sensitive and resistant high-grade serous ovarian cancer: development and applications of experimental systems

Title: Modeling platinum sensitive and resistant high-grade serous ovarian cancer: development and applications of experimental systems
Authors: Cunnea, P
Stronach, EA
Item Type: Journal Article
Abstract: High-grade serous ovarian cancer remains the most common sub-type of ovarian cancer and, characterized by high degrees of genomic instability and heterogeneity, is typified by a transition from early response to acquired resistance to platinum-based chemotherapy. Conventional models for the study of ovarian cancer have been largely limited to a set of relatively poorly characterized immortalized cell lines and recent studies have called into question the validity of some of these as reliable models. Here, we review new approaches and models systems that take into account advances in our understanding of ovarian cancer biology and advances in the technology available for their generation and study. We discuss primary cell models, 2D, 3D, and organotypic models, and paired sample approaches that capture the evolution of chemotherapy failure within single cases. We also overview new methods for non-invasive collection of representative tumor material from blood samples. Adoption of such methods and models will improve the quality and clinical relevance of ovarian cancer research.
Issue Date: 17-Apr-2014
Date of Acceptance: 2-Apr-2014
ISSN: 2234-943X
Publisher: Frontiers Media
Journal / Book Title: Frontiers in Oncology
Volume: 4
Copyright Statement: © 2014 Cunnea and Stronach. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
Sponsor/Funder: Commission of the European Communities
Funder's Grant Number: 279113
Keywords: high-grade serous ovarian cancer
platinum sensitive
tumor heterogeneity
Publication Status: Published
Article Number: 81
Appears in Collections:Division of Surgery
Division of Cancer
Faculty of Medicine

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