Pump function curve shape for a model lymphatic vessel

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Title: Pump function curve shape for a model lymphatic vessel
Authors: Bertram, CD
Macaskill, C
Moore Jr, JE
Item Type: Journal Article
Abstract: The transport capacity of a contractile segment of lymphatic vessel is defined by its pump function curve relating mean flow-rate and adverse pressure difference. Numerous system characteristics affect curve shape and the magnitude of the generated flow-rates and pressures. Some cannot be varied experimentally, but their separate and interacting effects can be systematically revealed numerically. This paper explores variations in the rate of change of active tension and the form of the relation between active tension and muscle length, factors not known from experiment to functional precision. Whether the pump function curve bends toward or away from the origin depends partly on the curvature of the passive pressure-diameter relation near zero transmural pressure, but rather more on the form of the relation between active tension and muscle length. A pump function curve bending away from the origin defines a well-performing pump by maximum steady output power. This behaviour is favoured by a length/active-tension relationship which sustains tension at smaller lengths. Such a relationship also favours high peak mechanical efficiency, defined as output power divided by the input power obtained from the lymphangion diameter changes and active-tension time-course. The results highlight the need to pin down experimentally the form of the active tension/length relationship.
Issue Date: 13-May-2016
Date of Acceptance: 8-Apr-2016
URI: http://hdl.handle.net/10044/1/31097
DOI: https://dx.doi.org/10.1016/j.medengphy.2016.04.009
ISSN: 1873-4030
Publisher: Elsevier
Start Page: 656
End Page: 663
Journal / Book Title: Medical Engineering & Physics
Volume: 38
Issue: 7
Copyright Statement: © 2016 IPEM. Published by Elsevier Ltd. All rights reserved. All rights reserved. This manuscript is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International http://creativecommons.org/licenses/by-nc-nd/4.0/
Sponsor/Funder: The Royal Society
Royal Academy Of Engineering
National Institutes of Health
National Institutes of Health
Funder's Grant Number: WM120065
N/A
TEES No. C09-00903
1U01HL123420-01
Keywords: Biomedical Engineering
02 Physical Sciences
09 Engineering
11 Medical And Health Sciences
Publication Status: Published
Appears in Collections:Faculty of Engineering
Bioengineering



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