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Optical Coherence Tomography for detection of compound action potential in Xenopus Laevis sciatic nerve

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Title: Optical Coherence Tomography for detection of compound action potential in Xenopus Laevis sciatic nerve
Authors: Troiani, F
Nikolic, K
Constandinou, TG
Item Type: Conference Paper
Abstract: Due to optical coherence tomography (OCT) high spatial and temporal resolution, this technique could be used to observe the quick changes in the refractive index that accompany action potential. In this study we explore the use of time domain Optical Coherence Tomography (TD-OCT) for real time action potential detection in ex vivo Xenopus Laevis sciatic nerve. TD-OCT is the easiest and less expensive OCT technique and, if successful in detecting real time action potential, it could be used for low cost monitoring devices. A theoretical investigation into the order of magnitude of the signals detected by a TD-OCT setup is provided by this work. A linear dependence between the refractive index and the intensity changes is observed and the minimum SNR for which the setup could work is found to be SNR = 2 x 10⁴ .
Issue Date: 18-Mar-2016
Date of Acceptance: 12-Oct-2015
URI: http://hdl.handle.net/10044/1/30124
DOI: https://dx.doi.org/10.1117/12.2209335
Copyright Statement: © 2016 SPIE (Society of Photo-Optical Instrumentation Engineers). One print or electronic copy may be made for personal use only. Systematic reproduction and distribution, duplication of any material in this paper for a fee or for commercial purposes, or modification of the content of the paper are prohibited.
Sponsor/Funder: Engineering & Physical Science Research Council (EPSRC)
Engineering & Physical Science Research Council (E
Biotechnology and Biological Sciences Research Council (BBSRC)
Funder's Grant Number: EP/G070466/1
EP/K503733/1
BB/L018268/1
Conference Name: SPIE Photonics West (BIOS)
Publication Status: Published
Start Date: 2016-02-13
Conference Place: San Francisco
Appears in Collections:Faculty of Engineering
Electrical and Electronic Engineering



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