Hydrogen Sulfide Prevents and Partially Reverses Ozone-induced Feature of Lung Inflammation and Emphysema in Mice.

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Title: Hydrogen Sulfide Prevents and Partially Reverses Ozone-induced Feature of Lung Inflammation and Emphysema in Mice.
Authors: Li, F
Zhang, P
Zhang, M
Liang, L
Sun, X
Li, M
Tang, Y
Bao, A
Gong, J
Zhang, JJ
Adcock, I
Chung, KF
Zhou, X
Item Type: Journal Article
Abstract: Hydrogen sulfide (H2S), a novel signaling gasotransmitter in the respiratory system, may have antiinflammatory properties in the lung. We examined the preventive and therapeutic effects of H2S on ozone-induced features of lung inflammation and emphysema. C57/BL6 mice were exposed to ozone or filtered air over 6 weeks. Sodium hydrogen sulfide (NaHS), an H2S donor, was administered to the mice either before ozone exposure (preventive effect) or after completion of 6 weeks of ozone exposure (therapeutic effect). The ozone-exposed mice developed emphysema, measured by micro-computed tomography and histology, airflow limitation, measured by the forced maneuver system, and increased lung inflammation with augmented IL-1β, IL-18, and matrix metalloproteinase-9 (MMP-9) gene expression. Ozone-induced changes were associated with increased Nod-like receptor pyrin domain containing 3 (NLRP3)-caspase-1 activation and p38 mitogen-activated protein kinase phosphorylation and decreased Akt phosphorylation. NaHS both prevented and reversed lung inflammation and emphysematous changes in alveolar space. In contrast, NaHS prevented, but did not reverse, ozone-induced airflow limitation and bronchial structural remodeling. In conclusion, NaHS administration prevented and partially reversed ozone-induced features of lung inflammation and emphysema via regulation of the NLRP3-caspase-1, p38 mitogen-activated protein kinase, and Akt pathways.
Issue Date: 5-Jan-2016
Date of Acceptance: 5-Jan-2016
URI: http://hdl.handle.net/10044/1/30008
DOI: https://dx.doi.org/10.1165/rcmb.2015-0014OC
ISSN: 1535-4989
Publisher: American Thoracic Society
Start Page: 72
End Page: 81
Journal / Book Title: American Journal of Respiratory Cell and Molecular Biology
Volume: 55
Issue: 1
Copyright Statement: Originally Published in:Feng Li, Pengyu Zhang, Min Zhang, Li Liang, Xiaoyuan Sun, Min Li, Yueqin Tang, Aihua Bao, Jicheng Gong, Junfeng (Jim) Zhang, Ian Adcock, Kian Fan Chung, and Xin Zhou. Hydrogen Sulfide Prevents and Partially Reverses Ozone-induced Feature of Lung Inflammation and Emphysema in Mice. American Journal of Respiratory Cell and Molecular Biology 2016; DOI: 10.1165/rcmb.2015-0014OC Copyright © 2014 by the American Thoracic Society The final publication is available at https://dx.doi.org/10.1165/rcmb.2015-0014OC
Keywords: emphysema
hydrogen sulfide
lung inflammation
ozone exposure
emphysema
hydrogen sulfide
lung inflammation
ozone exposure
Respiratory System
1102 Cardiovascular Medicine And Haematology
Publication Status: Published
Appears in Collections:National Heart and Lung Institute
Airway Disease
Faculty of Medicine



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