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Oxidative stress-induced mitochondrial dysfunction drives inflammation and airway smooth muscle remodeling in patients with chronic obstructive pulmonary disease

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Title: Oxidative stress-induced mitochondrial dysfunction drives inflammation and airway smooth muscle remodeling in patients with chronic obstructive pulmonary disease
Authors: Wiegman, CH
Michaeloudes, C
Haji, G
Narang, P
Clarke, CJ
Russell, KE
Bao, W
Pavlidis, S
Barnes, PJ
Kanerva, J
Bittner, A
Rao, N
Murphy, MP
Kirkham, PA
Chung, KF
Adcock, IM
Item Type: Journal Article
Issue Date: 1-Sep-2015
Date of Acceptance: 30-Jan-2015
URI: http://hdl.handle.net/10044/1/29981
DOI: http://dx.doi.org/10.1016/j.jaci.2015.01.046
ISSN: 1097-6825
Publisher: Elsevier
Start Page: 769
End Page: 780
Journal / Book Title: Journal of Allergy and Clinical Immunology
Volume: 136
Issue: 3
Copyright Statement: © 2015 The Authors. Published by Elsevier Inc. on behalf of the American Academy of Allergy, Asthma & Immunology. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
Keywords: Science & Technology
Life Sciences & Biomedicine
Allergy
Immunology
Ozone
inflammation
airway smooth muscle
mitochondria
chronic obstructive pulmonary disease
airway hyperresponsiveness
oxidative stress
antioxidant
proliferation
MitoQ
ENERGY-METABOLISM
ASTHMA FEATURES
ALLERGIC-ASTHMA
MURINE MODEL
OZONE
CELLS
COPD
MECHANISMS
IMMUNITY
BETA
MitoQ
Ozone
airway hyperresponsiveness
airway smooth muscle
antioxidant
chronic obstructive pulmonary disease
inflammation
mitochondria
oxidative stress
proliferation
Adult
Aged
Airway Remodeling
Animals
Antioxidants
Bronchial Hyperreactivity
Electron Transport Chain Complex Proteins
Female
Gene Expression Regulation
Humans
Hydrogen Peroxide
Male
Membrane Potential, Mitochondrial
Mice
Middle Aged
Mitochondria
Muscle, Smooth
Myocytes, Smooth Muscle
Organophosphorus Compounds
Oxidative Stress
Ozone
Pneumonia
Pulmonary Disease, Chronic Obstructive
Reactive Oxygen Species
Respiratory System
Signal Transduction
Smoking
Ubiquinone
COPDMAP
Muscle, Smooth
Respiratory System
Mitochondria
Myocytes, Smooth Muscle
Animals
Humans
Mice
Bronchial Hyperreactivity
Pulmonary Disease, Chronic Obstructive
Pneumonia
Hydrogen Peroxide
Ozone
Reactive Oxygen Species
Organophosphorus Compounds
Ubiquinone
Electron Transport Chain Complex Proteins
Antioxidants
Smoking
Signal Transduction
Gene Expression Regulation
Oxidative Stress
Adult
Aged
Middle Aged
Female
Male
Membrane Potential, Mitochondrial
Airway Remodeling
Science & Technology
Life Sciences & Biomedicine
Allergy
Immunology
Ozone
inflammation
airway smooth muscle
mitochondria
chronic obstructive pulmonary disease
airway hyperresponsiveness
oxidative stress
antioxidant
proliferation
MitoQ
ENERGY-METABOLISM
ASTHMA FEATURES
ALLERGIC-ASTHMA
MURINE MODEL
OZONE
CELLS
COPD
MECHANISMS
IMMUNITY
BETA
Allergy
1107 Immunology
Publication Status: Published
Appears in Collections:Faculty of Engineering
Computing
National Heart and Lung Institute
Airway Disease
Faculty of Medicine



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