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Promoter architectures and developmental gene regulation.

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Title: Promoter architectures and developmental gene regulation.
Authors: Haberle, V
Lenhard, B
Item Type: Journal Article
Abstract: Core promoters are minimal regions sufficient to direct accurate initiation of transcription and are crucial for regulation of gene expression. They are highly diverse in terms of associated core promoter motifs, underlying sequence composition and patterns of transcription initiation. Distinctive features of promoters are also seen at the chromatin level, including nucleosome positioning patterns and presence of specific histone modifications. Recent advances in identifying and characterizing promoters using next-generation sequencing-based technologies have provided the basis for their classification into functional groups and have shed light on their modes of regulation, with important implications for transcriptional regulation in development. This review discusses the methodology and the results of genome-wide studies that provided insight into the diversity of RNA polymerase II promoter architectures in vertebrates and other Metazoa, and the association of these architectures with distinct modes of regulation in embryonic development and differentiation.
Issue Date: 16-Jan-2016
Date of Acceptance: 11-Jan-2016
URI: http://hdl.handle.net/10044/1/29890
DOI: https://dx.doi.org/10.1016/j.semcdb.2016.01.014
ISSN: 1096-3634
Publisher: Elsevier
Start Page: 11
End Page: 23
Journal / Book Title: Seminars in Cell & Developmental Biology
Volume: 57
Copyright Statement: © 2016, Elsevier. Licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International http://creativecommons.org/licenses/by-nc-nd/4.0/
Sponsor/Funder: Biotechnology and Biological Sciences Research Council (BBSRC)
Funder's Grant Number: BB/L00741X/1
Keywords: CAGE
Core promoter
Overlapping codes
Promoter types
Transcription start sites
Transcriptional regulation
Developmental Biology
0601 Biochemistry And Cell Biology
1114 Paediatrics And Reproductive Medicine
Publication Status: Published
Appears in Collections:Clinical Sciences
Molecular Sciences
Faculty of Medicine



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