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Pulmonary artery stiffness is independently associated with right ventricular mass and function: a cardiac magnetic resonance study.

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Title: Pulmonary artery stiffness is independently associated with right ventricular mass and function: a cardiac magnetic resonance study.
Authors: Dawes, TJW
Gandhi, A
De Marvao, A
Buzaco, R
Tokarczuk, P
Quinlan, M
Durighel, G
Diamond, T
Monje Garcia, L
De Cesare, A
Cook, SA
O'Regan, DP
Item Type: Journal Article
Abstract: Purpose To determine the relationship between pulmonary artery (PA) stiffness and both right ventricular (RV) mass and function with cardiac magnetic resonance (MR) imaging. Materials and Methods The study was approved by the local research ethics committee, and all participants gave written informed consent. Cardiac MR imaging was performed at 1.5 T in 156 healthy volunteers (63% women; age range, 19-61 years; mean age, 36.1 years). High-temporal-resolution phase-contrast imaging was performed in the main and right PAs. Pulmonary pulse wave velocity (PWV) was determined by the interval between arterial systolic upslopes. RV function was assessed with feature tracking to derive peak systolic strain and strain rate, as well as peak early-diastolic strain rate. RV volumes, ejection fraction (RVEF), and mass were measured from the cine images. The association of pulmonary PWV with RV function and mass was quantified with univariate linear regression. Interstudy repeatability was assessed with intraclass correlation. Results The repeatability coefficient for pulmonary PWV was 0.96. Increases in pulmonary PWV and RVEF were associated with increases in age (r = 0.32, P < .001 and r = 0.18, P = .025, respectively). After adjusting for age (P = .090), body surface area (P = .073), and sex (P = .005), pulmonary PWV demonstrated an independent positive association with RVEF (r = 0.34, P = .026). Significant associations were also seen with RV mass (r = 0.41, P = .004), RV radial strain (r = 0.38, P = .022), and strain rate (r = 0.35, P = .002), and independent negative associations were seen with radial (r = 0.27, P = .003), longitudinal (r = 0.40, P = .007), and circumferential (r = 0.31, P = .005) peak early-diastolic strain rate with the same covariates. Conclusion Pulmonary PWV is reliably assessed with cardiac MR imaging. In subjects with no known cardiovascular disease, increasing PA stiffness is associated with increasing age and is also moderately associated with both RV mass and function after controlling for age, body surface area, and sex. (©) RSNA, 2016 Online supplemental material is available for this article.
Issue Date: 24-Feb-2016
Date of Acceptance: 15-Dec-2015
URI: http://hdl.handle.net/10044/1/29835
DOI: https://dx.doi.org/10.1148/radiol.2016151527
ISSN: 1527-1315
Publisher: Radiological Society of North America (RSNA)
Journal / Book Title: Radiology
Volume: 280
Issue: 2
Copyright Statement: © RSNA, 2016
Sponsor/Funder: Imperial College Healthcare NHS Trust- BRC Funding
British Heart Foundation
Funder's Grant Number: RD410
PG/12/27/29489
Keywords: Nuclear Medicine & Medical Imaging
11 Medical And Health Sciences
Publication Status: Published
Appears in Collections:Clinical Sciences
Imaging Sciences
National Heart and Lung Institute
Molecular Sciences
Faculty of Medicine



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