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Positron emission tomography imaging of tumor cell metabolism and application to therapy response monitoring

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Title: Positron emission tomography imaging of tumor cell metabolism and application to therapy response monitoring
Authors: Aboagye, EO
Challapalli, A
Item Type: Journal Article
Abstract: Cancer cells do reprogram their energy metabolism to enable several functions, such as generation of biomass including membrane biosynthesis, and overcoming bioenergetic and redox stress. In this article, we review both established and evolving radioprobes developed in association with positron emission tomography (PET) to detect tumor cell metabolism and effect of treatment. Measurement of enhanced tumor cell glycolysis using 2-deoxy-2-[(18)F]fluoro-D-glucose is well established in the clinic. Analogs of choline, including [(11)C]choline and various fluorinated derivatives are being tested in several cancer types clinically with PET. In addition to these, there is an evolving array of metabolic tracers for measuring intracellular transport of glutamine and other amino acids or for measuring glycogenesis, as well as probes used as surrogates for fatty acid synthesis or precursors for fatty acid oxidation. In addition to providing us with opportunities for examining the complex regulation of reprogramed energy metabolism in living subjects, the PET methods open up opportunities for monitoring pharmacological activity of new therapies that directly or indirectly inhibit tumor cell metabolism.
Issue Date: 29-Feb-2016
Date of Acceptance: 12-Feb-2016
URI: http://hdl.handle.net/10044/1/29724
DOI: https://dx.doi.org/10.3389/fonc.2016.00044
ISSN: 2234-943X
Publisher: Frontiers
Journal / Book Title: Frontiers in Oncology
Volume: 6
Copyright Statement: © 2016 Challapalli and Aboagye. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
Keywords: acetate
choline
glutamine
methionine
positron emission tomography
tumor metabolism
Publication Status: Published
Article Number: 44
Appears in Collections:Division of Surgery
Division of Cancer
Faculty of Medicine



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