Synthesis and characterisation of 5-acyl-6,7-dihydrothieno[3,2-c]pyridine inhibitors of Hedgehog acyltransferase

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Title: Synthesis and characterisation of 5-acyl-6,7-dihydrothieno[3,2-c]pyridine inhibitors of Hedgehog acyltransferase
Authors: Lanyon-Hogg, T
Masumoto, N
Bodakh, G
Konitsiotis, AD
Thinon, E
Rodgers, UR
Owens, RJ
Magee, AI
Tate, EW
Item Type: Journal Article
Abstract: © 2016 The Authors.In this data article we describe synthetic and characterisation data for four members of the 5-acyl-6,7-dihydrothieno[3,2-c]pyridine (termed RU-SKI ) class of inhibitors of Hedgehog acyltransferase, including associated NMR spectra for final compounds. RU-SKI compounds were selected for synthesis based on their published high potencies against the enzyme target. RU-SKI 41 (9a), RU-SKI 43 (9b), RU-SKI 101 (9c), and RU-SKI 201 (9d) were profiled for activity in the related article Click chemistry armed enzyme linked immunosorbent assay to measure palmitoylation by Hedgehog acyltransferase (Lanyon-Hogg et al., 2015) [1]. 1H NMR spectral data indicate different amide conformational ratios between the RU-SKI inhibitors, as has been observed in other 5-acyl-6,7-dihydrothieno[3,2-c]pyridines. The synthetic and characterisation data supplied in the current article provide validated access to the class of RU-SKI inhibitors.
Issue Date: 10-Feb-2016
Date of Acceptance: 1-Feb-2016
URI: http://hdl.handle.net/10044/1/29712
DOI: https://dx.doi.org/10.1016/j.dib.2016.02.012
ISSN: 2352-3409
Publisher: Elsevier
Start Page: 257
End Page: 281
Journal / Book Title: Data in Brief
Volume: 7
Copyright Statement: © 2016 Published by Elsevier Inc. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/)
Sponsor/Funder: Cancer Research UK
Funder's Grant Number: C6433/A16402
Keywords: Conformation
Hedgehog acyltransferase
Inhibitors
Synthesis
Publication Status: Published
Open Access location: http://www.sciencedirect.com/science/article/pii/S2352340916300348
Appears in Collections:Chemistry
Biological and Biophysical Chemistry
National Heart and Lung Institute
Faculty of Medicine
Faculty of Natural Sciences



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