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Whole Genome Sequence Analysis Suggests Intratumoral Heterogeneity in Dissemination of Breast Cancer to Lymph Nodes

Title: Whole Genome Sequence Analysis Suggests Intratumoral Heterogeneity in Dissemination of Breast Cancer to Lymph Nodes
Authors: Blighe, K
Kenny, L
Patel, N
Guttery, DS
Page, K
Gronau, JH
Golshani, C
Stebbing, J
Coombes, RC
Shaw, JA
Item Type: Journal Article
Issue Date: 29-Dec-2014
Date of Acceptance: 22-Nov-2014
URI: http://hdl.handle.net/10044/1/29186
DOI: https://dx.doi.org/10.1371/journal.pone.0115346
ISSN: 1932-6203
Publisher: Public Library of Science
Journal / Book Title: PLOS One
Volume: 9
Issue: 12
Copyright Statement: © 2014 Blighe et al. This is an openaccess article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Sponsor/Funder: National Institute for Health Research
Cancer Research UK
Funder's Grant Number: NIHR-RP-011-053
C27532/A14549
Keywords: Science & Technology
Multidisciplinary Sciences
Science & Technology - Other Topics
CHROMOSOMAL INSTABILITY
GENE-EXPRESSION
CLINICAL-IMPLICATIONS
CLONAL EVOLUTION
TP53 MUTATIONS
OVEREXPRESSION
METASTASIS
CARCINOMAS
REVEALS
DISEASE
Adaptor Proteins, Signal Transducing
Antigens, Neoplasm
Breast Neoplasms
Cyclin B2
DNA Topoisomerases, Type II
DNA-Binding Proteins
Female
GTPase-Activating Proteins
Genetic Heterogeneity
Genome, Human
Homeodomain Proteins
Humans
Lymphatic Metastasis
Polymorphism, Single Nucleotide
Repressor Proteins
Transcription Factors
Tumor Suppressor Protein p53
General Science & Technology
MD Multidisciplinary
Publication Status: Published
Article Number: e115346
Appears in Collections:Division of Surgery
Division of Cancer
Faculty of Medicine



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