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Leptin induces upregulation of sphingosine kinase 1 in oestrogen receptor-negative breast cancer via Src family kinase-mediated, janus kinase 2-independent pathway

Title: Leptin induces upregulation of sphingosine kinase 1 in oestrogen receptor-negative breast cancer via Src family kinase-mediated, janus kinase 2-independent pathway
Authors: Alshaker, H
Krell, J
Frampton, AE
Waxman, J
Blyuss, O
Zaikin, A
Winkler, M
Stebbing, J
Yaguee, E
Pchejetski, D
Item Type: Journal Article
Issue Date: 25-Oct-2014
Date of Acceptance: 11-Aug-2014
URI: http://hdl.handle.net/10044/1/29185
DOI: https://dx.doi.org/10.1186/s13058-014-0426-6
ISSN: 1465-542X
Publisher: BioMed Central
Journal / Book Title: Breast Cancer Research
Volume: 16
Issue: 5
Copyright Statement: © 2014 Alshaker et al.; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
Sponsor/Funder: National Institute for Health Research
Cancer Research UK
Funder's Grant Number: NIHR-RP-011-053
C27532/A14549
Keywords: Science & Technology
Life Sciences & Biomedicine
Oncology
ACTIVATED PROTEIN-KINASES
SIGNALING PATHWAYS
PROSTATE-CANCER
MESSENGER-RNA
CELL-LINES
EXPRESSION
OBESITY
INHIBITION
1-PHOSPHATE
GROWTH
Breast Neoplasms
Cell Proliferation
Enzyme Induction
Female
Gene Expression Regulation, Neoplastic
Humans
Janus Kinase 2
Leptin
Lymphatic Metastasis
MCF-7 Cells
Obesity
Phosphorylation
Phosphotransferases (Alcohol Group Acceptor)
Protein Processing, Post-Translational
Protein Tyrosine Phosphatase, Non-Receptor Type 11
Receptors, Estrogen
Receptors, Leptin
Signal Transduction
Up-Regulation
Vascular Endothelial Growth Factor A
src-Family Kinases
Oncology & Carcinogenesis
1112 Oncology And Carcinogenesis
Publication Status: Published
Article Number: 426
Appears in Collections:Division of Surgery
Division of Cancer
Faculty of Medicine



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