SILAC-based phosphoproteomics reveals an inhibitory role of KSR1 in p53 transcriptional activity via modulation of DBC1

Title: SILAC-based phosphoproteomics reveals an inhibitory role of KSR1 in p53 transcriptional activity via modulation of DBC1
Author(s): Zhang, H
Xu, Y
Filipovic, A
Lit, LC
Koo, C-Y
Stebbing, J
Giamas, G
Item Type: Journal Article
Publication Date: 12-Nov-2013
Date of Acceptance: 18-Sep-2013
URI: http://hdl.handle.net/10044/1/29184
DOI: https://dx.doi.org/10.1038/bjc.2013.628
ISSN: 1532-1827
Publisher: Cancer Research UK
Start Page: 2675
End Page: 2684
Journal / Book Title: British Journal of Cancer
Volume: 109
Issue: 10
Copyright Statement: © 2013 Cancer Research UK. Under a Creative Commons Attribution Non-Commercial Share Alike License
Sponsor/Funder: National Institute for Health Research
Cancer Research UK
Funder's Grant Number: NIHR-RP-011-053
C27532/A14549
Keywords: Science & Technology
Life Sciences & Biomedicine
Oncology
ONCOLOGY
SILAC
KSR1
p53
DBC1
acetylation
ACTIVATED PROTEIN-KINASE
BREAST-CANCER
SIRT1 DEACETYLASE
GENE-EXPRESSION
DNA-DAMAGE
RAS
SUPPRESSOR
PHOSPHORYLATION
ACETYLATION
MECHANISM
Amino Acids
Breast Neoplasms
Cell Culture Techniques
Down-Regulation
Female
Gene Expression Regulation, Neoplastic
HCT116 Cells
Humans
Isotope Labeling
Phosphoproteins
Protein Kinases
Proteomics
Sirtuin 1
Transcriptional Activation
Tumor Cells, Cultured
Tumor Suppressor Protein p53
Tumor Suppressor Proteins
HCT116 Cells
Tumor Cells, Cultured
Humans
Breast Neoplasms
Protein Kinases
Amino Acids
Tumor Suppressor Proteins
Phosphoproteins
Cell Culture Techniques
Isotope Labeling
Proteomics
Down-Regulation
Gene Expression Regulation, Neoplastic
Female
Tumor Suppressor Protein p53
Transcriptional Activation
Sirtuin 1
Science & Technology
Life Sciences & Biomedicine
Oncology
ONCOLOGY
SILAC
KSR1
p53
DBC1
acetylation
ACTIVATED PROTEIN-KINASE
BREAST-CANCER
SIRT1 DEACETYLASE
GENE-EXPRESSION
DNA-DAMAGE
RAS
SUPPRESSOR
PHOSPHORYLATION
ACETYLATION
MECHANISM
Oncology & Carcinogenesis
1112 Oncology And Carcinogenesis
Publication Status: Published
Appears in Collections:Division of Surgery
Division of Cancer
Faculty of Medicine



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