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SILAC-based phosphoproteomics reveals an inhibitory role of KSR1 in p53 transcriptional activity via modulation of DBC1

Title: SILAC-based phosphoproteomics reveals an inhibitory role of KSR1 in p53 transcriptional activity via modulation of DBC1
Authors: Zhang, H
Xu, Y
Filipovic, A
Lit, LC
Koo, C-Y
Stebbing, J
Giamas, G
Item Type: Journal Article
Issue Date: 12-Nov-2013
Date of Acceptance: 18-Sep-2013
URI: http://hdl.handle.net/10044/1/29184
DOI: https://dx.doi.org/10.1038/bjc.2013.628
ISSN: 1532-1827
Publisher: Cancer Research UK
Start Page: 2675
End Page: 2684
Journal / Book Title: British Journal of Cancer
Volume: 109
Issue: 10
Copyright Statement: © 2013 Cancer Research UK. Under a Creative Commons Attribution Non-Commercial Share Alike License
Sponsor/Funder: National Institute for Health Research
Cancer Research UK
Funder's Grant Number: NIHR-RP-011-053
C27532/A14549
Keywords: Science & Technology
Life Sciences & Biomedicine
Oncology
ONCOLOGY
SILAC
KSR1
p53
DBC1
acetylation
ACTIVATED PROTEIN-KINASE
BREAST-CANCER
SIRT1 DEACETYLASE
GENE-EXPRESSION
DNA-DAMAGE
RAS
SUPPRESSOR
PHOSPHORYLATION
ACETYLATION
MECHANISM
Amino Acids
Breast Neoplasms
Cell Culture Techniques
Down-Regulation
Female
Gene Expression Regulation, Neoplastic
HCT116 Cells
Humans
Isotope Labeling
Phosphoproteins
Protein Kinases
Proteomics
Sirtuin 1
Transcriptional Activation
Tumor Cells, Cultured
Tumor Suppressor Protein p53
Tumor Suppressor Proteins
Oncology & Carcinogenesis
1112 Oncology And Carcinogenesis
Publication Status: Published
Appears in Collections:Division of Surgery
Division of Cancer
Faculty of Medicine



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