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Genome-Wide Association Identifies Nine Common Variants Associated With Fasting Proinsulin Levels and Provides New Insights Into the Pathophysiology of Type 2 Diabetes

Title: Genome-Wide Association Identifies Nine Common Variants Associated With Fasting Proinsulin Levels and Provides New Insights Into the Pathophysiology of Type 2 Diabetes
Authors: Strawbridge, RJ
Dupuis, J
Prokopenko, I
Barker, A
Ahlqvist, E
Rybin, D
Petrie, JR
Travers, ME
Bouatia-Naji, N
Dimas, AS
Nica, A
Wheeler, E
Chen, H
Voight, BF
Taneera, J
Kanoni, S
Peden, JF
Turrini, F
Gustafsson, S
Zabena, C
Almgren, P
Barker, DJP
Barnes, D
Dennison, EM
Eriksson, JG
Eriksson, P
Eury, E
Folkersen, L
Fox, CS
Frayling, TM
Goel, A
Gu, HF
Horikoshi, M
Isomaa, B
Jackson, AU
Jameson, KA
Kajantie, E
Kerr-Conte, J
Kuulasmaa, T
Kuusisto, J
Loos, RJF
Luan, J
Makrilakis, K
Manning, AK
Teresa Martinez-Larrad, M
Narisu, N
Mannila, MN
Ohrvik, J
Osmond, C
Pascoe, L
Payne, F
Sayer, AA
Sennblad, B
Silveira, A
Stancakova, A
Stirrups, K
Swift, AJ
Syvanen, A-C
Tuomi, T
Van 't Hooft, FM
Walker, M
Weedon, MN
Xie, W
Zethelius, B
Ongen, H
Malarstig, A
Hopewell, JC
Saleheen, D
Chambers, J
Parish, S
Danesh, J
Kooner, J
Ostenson, C-G
Lind, L
Cooper, CC
Serrano-Rios, M
Ferrannini, E
Forsen, TJ
Clarke, R
Franzosi, MG
Seedorf, U
Watkins, H
Froguel, P
Johnson, P
Deloukas, P
Collins, FS
Laakso, M
Dermitzakis, ET
Boehnke, M
McCarthy, MI
Wareham, NJ
Groop, L
Pattou, F
Gloyn, AL
Dedoussis, GV
Lyssenko, V
Meigs, JB
Barroso, I
Watanabe, RM
Ingelsson, E
Langenberg, C
Hamsten, A
Florez, JC
Item Type: Journal Article
Issue Date: 1-Oct-2011
Date of Acceptance: 29-Jun-2011
URI: http://hdl.handle.net/10044/1/28755
DOI: https://dx.doi.org/10.2337/db11-0415
ISSN: 0012-1797
Publisher: American Diabetes Association
Start Page: 2624
End Page: 2634
Journal / Book Title: Diabetes
Volume: 60
Issue: 10
Copyright Statement: © 2011 by the American Diabetes Association. Readers may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered. See http://creativecommons.org/licenses/by-nc-nd/3.0/ for details.
Sponsor/Funder: Medical Research Council (MRC)
Medical Research Council (MRC)
Medical Research Council (MRC)
Medical Research Council (MRC)
Funder's Grant Number: G0700931
G0601966
G0801056B
G0801056/1
Keywords: Science & Technology
Life Sciences & Biomedicine
Endocrinology & Metabolism
ENDOCRINOLOGY & METABOLISM
CORONARY HEART-DISEASE
BETA-CELL FUNCTION
SUSCEPTIBILITY LOCI
GLUCOSE-HOMEOSTASIS
INSULIN SENSITIVITY
POPULATION
TCF7L2
RISK
OBESITY
METAANALYSIS
Adult
Diabetes Mellitus, Type 2
Fasting
Female
Genetic Variation
Genome, Human
Genotype
Humans
Insulin
Male
Polymorphism, Single Nucleotide
Proinsulin
DIAGRAM Consortium
GIANT Consortium
MuTHER Consortium
CARDIoGRAM Consortium
C4D Consortium
11 Medical And Health Sciences
Publication Status: Published
Appears in Collections:Department of Medicine
Faculty of Medicine
Epidemiology, Public Health and Primary Care



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