Detection of the complement fragment C5a in inflammatory exudates from the rabbit peritoneal cavity using radioimmunoassay.

Title: Detection of the complement fragment C5a in inflammatory exudates from the rabbit peritoneal cavity using radioimmunoassay.
Authors: Jose, PJ
Forrest, MJ
Williams, TJ
Item Type: Journal Article
Abstract: We describe a radioimmunoassay for rabbit C5a and its use to obtain evidence of extravascular C5a generation in two inflammatory reactions in the peritoneal cavity. These observations, together with the potent activity of C5a in inducing increased microvascular permeability involving circulating PMN leukocytes, strengthen the case for considering C5a an important inflammatory mediator. These findings offer an explanation for the many different experimental inflammatory reactions where oedema formation can be suppressed either by systemic depletion of complement or by depletion of circulating PMN leukocytes.
Issue Date: 1-Dec-1983
URI: http://hdl.handle.net/10044/1/28147
ISSN: 0022-1007
Start Page: 2177
End Page: 2182
Journal / Book Title: Journal of Experimental Medicine
Volume: 158
Issue: 6
Copyright Statement: © 1983 The Authors
Keywords: Animals
Complement C5
Complement C5a
Inflammation
Male
Peritoneal Cavity
Rabbits
Radioimmunoassay
Zymosan
Publication Status: Published
Appears in Collections:National Heart and Lung Institute
Airway Disease
Faculty of Medicine



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