Prospects for optogenetic augmentation of brain function

File Description SizeFormat 
153797_Schultz_ProvisionalPDF.pdfAccepted version3.93 MBAdobe PDFDownload
fnsys-09-00157.pdfPublished version738.05 kBAdobe PDFDownload
Title: Prospects for optogenetic augmentation of brain function
Author(s): Jarvis, S
Schultz, SR
Item Type: Journal Article
Abstract: The ability to optically control neural activity opens up possibilities for the restoration of normal function following neurological disorders. The temporal precision, spatial resolution, and neuronal specificity that optogenetics offers is unequalled by other available methods, so will it be suitable for not only restoring but also extending brain function? As the first demonstrations of optically implanted novel memories emerge, we examine the suitability of optogenetics as a technique for extending neural function. While optogenetics is an effective tool for altering neural activity, the largest impediment for optogenetics in neural augmentation is our systems level understanding of brain function. Furthermore, a number of clinical limitations currently remain as substantial hurdles for the applications proposed. While neurotechnologies for treating brain disorders and interfacing with prosthetics have advanced rapidly in the past few years, partially addressing some of these critical problems, optogenetics is not yet suitable for use in humans. Instead we conclude that for the immediate future, optogenetics is the neurological equivalent of the 3D printer: its flexibility providing an ideal tool for testing and prototyping solutions for treating brain disorders and augmenting brain function.
Publication Date: 31-Jan-2015
Date of Acceptance: 29-Oct-2015
ISSN: 1663-3563
Publisher: Frontiers
Journal / Book Title: Frontiers in Systems Neuroscience
Volume: 9
Copyright Statement: © 2015 Jarvis and Schultz. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
Article Number: 157
Appears in Collections:Faculty of Engineering

Items in Spiral are protected by copyright, with all rights reserved, unless otherwise indicated.

Creative Commons