Self-Assembled Wound Dressings Silence MMP-9 and Improve Diabetic Wound Healing In Vivo

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Title: Self-Assembled Wound Dressings Silence MMP-9 and Improve Diabetic Wound Healing In Vivo
Author(s): Castleberry, SA
Almquist, BD
Li, W
Reis, T
Chow, J
Mayner, S
Hammond, PT
Item Type: Journal Article
Abstract: The direct local delivery of short interfering RNA (siRNA) into target tissues presents a real solution to several complex medical conditions that today lack efficacious therapies. The development of an ultrathin polymer coating is described to sustain the delivery of siRNA for up to 2 weeks in vitro and in vivo. This technology successfully reduces the expression of MMP-9 within the wounds of diabetic mice, significantly accelerating the wound healing process and improving the quality of tissue formed.
Publication Date: 23-Dec-2015
Date of Acceptance: 15-Nov-2015
URI: http://hdl.handle.net/10044/1/27708
DOI: https://dx.doi.org/10.1002/adma.201503565
ISSN: 1521-4095
Publisher: Wiley-VCH Verlag
Start Page: 1809
End Page: 1817
Journal / Book Title: Advanced Materials
Volume: 28
Issue: 9
Copyright Statement: This is the peer reviewed version of the following article: Castleberry, S. A., Almquist, B. D., Li, W., Reis, T., Chow, J., Mayner, S. and Hammond, P. T. (2016), Self-Assembled Wound Dressings Silence MMP-9 and Improve Diabetic Wound Healing In Vivo. Adv. Mater., 28: 1809–1817., which has been published in final form at https://dx.doi.org/10.1002/adma.201503565.  This article may be used for non-commercial purposes in accordance With Wiley Terms and Conditions for self-archiving.
Keywords: controlled local delivery
diabetic wound healing
layer-by-layer
polymer coatings
siRNA delivery
Nanoscience & Nanotechnology
02 Physical Sciences
03 Chemical Sciences
09 Engineering
Publication Status: Published
Appears in Collections:Faculty of Engineering
Bioengineering



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