Long-term exposure to PM10 and NO2 in association with lung volume and airway resistance in the MAAS birth cohort.

Title: Long-term exposure to PM10 and NO2 in association with lung volume and airway resistance in the MAAS birth cohort.
Authors: Mölter, A
Agius, RM
de Vocht, F
Lindley, S
Gerrard, W
Lowe, L
Belgrave, D
Custovic, A
Simpson, A
Item Type: Journal Article
Abstract: BACKGROUND: Findings from previous studies on the effects of air pollution exposure on lung function during childhood have been inconsistent. A common limitation has been the quality of exposure data used, and few studies have modeled exposure longitudinally throughout early life. OBJECTIVES: We sought to study the long-term effects of exposure to particulate matter with an aerodynamic diameter ≤ 10 μm (PM10) and to nitrogen dioxide (NO2) on specific airway resistance (sR(aw)) and forced expiratory volume in 1 sec (FEV1) before and after bronchodilator treatment. Subjects were from the Manchester Asthma and Allergy Study (MAAS) birth cohort (n = 1,185). METHODS: Spirometry was performed during clinic visits at ages 3, 5, 8, and 11 years. Individual-level PM10 and NO2 exposures were estimated from birth to 11 years of age through a microenvironmental exposure model. Longitudinal and cross-sectional associations were estimated using generalized estimating equations and multivariable linear regression models. RESULTS: Lifetime exposure to PM10 and NO2 was associated with significantly less growth in FEV1 (percent predicted) over time, both before (-1.37%; 95% CI: -2.52, -0.23 for a 1-unit increase in PM10 and -0.83%; 95% CI: -1.39, -0.28 for a 1-unit increase in NO2) and after bronchodilator treatment (-3.59%; 95% CI: -5.36, -1.83 and -1.20%; 95% CI: -1.97, -0.43, respectively). We found no association between lifetime exposure and sR(aw) over time. Cross-sectional analyses of detailed exposure estimates for the summer and winter before 11 years of age and lung function at 11 years indicated no significant associations. CONCLUSIONS: Long-term PM10 and NO2 exposures were associated with small but statistically significant reductions in lung volume growth in children of elementary-school age.
Issue Date: 1-Oct-2013
Date of Acceptance: 17-Jun-2013
URI: http://hdl.handle.net/10044/1/27066
DOI: https://dx.doi.org/10.1289/ehp.1205961
ISSN: 1552-9924
Publisher: National Institute of Environmental Health Sciences (NIEHS)
Start Page: 1232
End Page: 1238
Journal / Book Title: Environmental Health Perspectives
Volume: 121
Issue: 10
Copyright Statement: Mölter A, Agius RM, de Vocht F, Lindley S, Gerrard W, Lowe L, Belgrave D, Custovic A, Simpson A. 2013. Long-term exposure to PM10 and NO2 in association with lung volume and airway resistance in the MAAS birth cohort. Environ Health Perspect 121:1232–1238. http://dx.doi.org/10.1289/ehp.1205961. Reproduced with permission from Environmental Health Perspectives.
Keywords: Air Pollutants
Airway Resistance
Child
Child, Preschool
Cohort Studies
Female
Humans
Lung
Male
Nitrogen Dioxide
Particulate Matter
Spirometry
Publication Status: Published
Appears in Collections:Department of Medicine
Faculty of Medicine



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