Modeling the biomechanics of fetal movements

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Title: Modeling the biomechanics of fetal movements
Authors: Verbruggen, SW
Loo, JHW
Hayat, TTA
Hajnal, JV
Rutherfor, MA
Phillips, ATM
Nowlan, NC
Item Type: Journal Article
Publication Date: 2015-11-03
Abstract: © 2015 The Author(s)Fetal movements in the uterus are a natural part of development and are known to play an important role in normal musculoskeletal development. However, very little is known about the biomechanical stimuli that arise during movements in utero, despite these stimuli being crucial to normal bone and joint formation. Therefore, the objective of this study was to create a series of computational steps by which the forces generated during a kick in utero could be predicted from clinically observed fetal movements using novel cine-MRI data of three fetuses, aged 20–22 weeks. A custom tracking software was designed to characterize the movements of joints in utero, and average uterus deflection of (Formula presented.) mm due to kicking was calculated. These observed displacements provided boundary conditions for a finite element model of the uterine environment, predicting an average reaction force of (Formula presented.) N generated by a kick against the uterine wall. Finally, these data were applied as inputs for a musculoskeletal model of a fetal kick, resulting in predicted maximum forces in the muscles surrounding the hip joint of approximately 8 N, while higher maximum forces of approximately 21 N were predicted for the muscles surrounding the knee joint. This study provides a novel insight into the closed mechanical environment of the uterus, with an innovative method allowing elucidation of the biomechanical interaction of the developing fetus with its surroundings.
Issue Date: 3-Nov-2015
Date of Acceptance: 7-Oct-2015
URI: http://hdl.handle.net/10044/1/26738
DOI: https://dx.doi.org/10.1007/s10237-015-0738-1
ISSN: 1617-7959
Publisher: Springer Verlag (Germany)
Start Page: 995
End Page: 1004
Journal / Book Title: Biomechanics and Modeling in Mechanobiology
Volume: 15
Issue: 4
Copyright Statement: © The Author(s) 2015. This article is published with open access at Springerlink.com
Sponsor/Funder: Arthritis Research UK
Funder's Grant Number: 20683
Keywords: Cine MRI
Computational model
Developmental dysplasia of the hip
Joint biomechanics
Musculoskeletal development
Biomedical Engineering
0913 Mechanical Engineering
0903 Biomedical Engineering
Publication Status: Published
Appears in Collections:Faculty of Engineering
Civil and Environmental Engineering
Bioengineering



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