Combination Growth Factor Therapy via Electrostatically Assembled Wound Dressings Improves Diabetic Ulcer Healing In Vivo

File Description SizeFormat 
AHM_submission_FINAL.pdfAccepted version1.96 MBAdobe PDFDownload
Supplementary Information.pdfSupporting information4.51 MBAdobe PDFDownload
Title: Combination Growth Factor Therapy via Electrostatically Assembled Wound Dressings Improves Diabetic Ulcer Healing In Vivo
Author(s): Almquist, BD
Castleberry, SA
Sun, JB
Lu, AY
Hammond, PT
Item Type: Journal Article
Abstract: Chronic skin ulcerations are a common complication of diabetes mellitus, affecting up to one in four diabetic individuals. Despite the prevalence of these wounds, current pharmacologic options for treating them remain limited. Growth factor-based therapies have displayed a mixed ability to drive successful healing, which may be due to nonoptimal delivery strategies. Here, a method for coating commercially available nylon dressings using the layer-by-layer process is described to enable both sustained release and independent control over the release kinetics of vascular endothelial growth factor 165 and platelet-derived growth factor BB. It is shown that the use of strategically spaced diffusion barriers formed spontaneously by disulfide bonds enables independent control over the release rates of incorporated growth factors, and that in vivo these dressings improve several aspects of wound healing in db/db mice.
Publication Date: 13-Aug-2015
Date of Acceptance: 15-Jul-2015
URI: http://hdl.handle.net/10044/1/25100
DOI: https://dx.doi.org/10.1002/adhm.201500403
ISSN: 2192-2640
Publisher: Wiley
Start Page: 2090
End Page: 2099
Journal / Book Title: Advanced Healthcare Materials
Volume: 4
Issue: 14
Copyright Statement: © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. This is the peer reviewed version of the following article: Almquist, B. D., Castleberry, S. A., Sun, J. B., Lu, A. Y. and Hammond, P. T. (2015), Combination Growth Factor Therapy via Electrostatically Assembled Wound Dressings Improves Diabetic Ulcer Healing In Vivo. Advanced Healthcare Materials, which has been published in final form at https://dx.doi.org/10.1002/adhm.201500403. This article may be used for non-commercial purposes in accordance With Wiley Terms and Conditions for self-archiving.
Keywords: chronic wound healing
diabetic ulcer
electrostatic assembly
growth factor
layer-by-layer
Publication Status: Published
Appears in Collections:Faculty of Engineering
Bioengineering



Items in Spiral are protected by copyright, with all rights reserved, unless otherwise indicated.

Creative Commons