The role of the interferon gamma release assay in assessing recent tuberculosis transmission in a hospital incident

Title: The role of the interferon gamma release assay in assessing recent tuberculosis transmission in a hospital incident
Authors: Bradshaw, L
Davies, E
Devine, M
Flanagan, P
Kelly, P
O'Connor, K
Drobniewski, F
Nikolayevskyy, V
Abubakar, I
Item Type: Journal Article
Abstract: In 2007, an extensive contact screening investigation into onward transmission of tuberculosis was instigated at a hospital in Northern Ireland following diagnosis of pulmonary multi-drug resistant TB in a healthcare worker. Interferon gamma release assays (IGRAs) were used to test 333 patients and 98 staff. We investigated for evidence of onward transmission and recent infection based on analysis of clinical, demographic and IGRA data. We also described within-patient variability of IGRA results. Among patients and staff, increasing age of patients was the only factor associated with IGRA positivity. Greatest within-subject variability of IU/mL in serially-tested patients/staff was seen in those with a positive IGRA test and this did not correlate with increased exposure to the index case. IGRA positivity being largely explained by increasing age in patients and previous TB contact in staff lends weight to the conclusion that IGRA positivity reflected previous infection rather than recent transmission. © 2011 Bradshaw et al.
Issue Date: 13-Jun-2011
Date of Acceptance: 9-May-2011
URI: http://hdl.handle.net/10044/1/23753
DOI: https://dx.doi.org/10.1371/journal.pone.0020770
ISSN: 1932-6203
Publisher: Public Library of Science
Journal / Book Title: PLOS One
Volume: 6
Issue: 6
Copyright Statement: © 2011 Bradshaw et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Publication Status: Published
Article Number: e20770
Appears in Collections:Department of Medicine
Faculty of Medicine



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