Next-generation sequencing: applications beyond genomes.

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Title: Next-generation sequencing: applications beyond genomes.
Authors: Marguerat, S
Wilhelm, BT
Bähler, J
Item Type: Journal Article
Abstract: The development of DNA sequencing more than 30 years ago has profoundly impacted biological research. In the last couple of years, remarkable technological innovations have emerged that allow the direct and cost-effective sequencing of complex samples at unprecedented scale and speed. These next-generation technologies make it feasible to sequence not only static genomes, but also entire transcriptomes expressed under different conditions. These and other powerful applications of next-generation sequencing are rapidly revolutionizing the way genomic studies are carried out. Below, we provide a snapshot of these exciting new approaches to understanding the properties and functions of genomes. Given that sequencing-based assays may increasingly supersede microarray-based assays, we also compare and contrast data obtained from these distinct approaches.
Issue Date: 1-Oct-2008
ISSN: 1470-8752
Publisher: Portland Press
Start Page: 1091
End Page: 1096
Journal / Book Title: Biochemical Society Transactions
Volume: 36
Issue: 5
Copyright Statement: © 2008 The Author(s) The author(s) has paid for this article to be freely available under the terms of the Creative Commons Attribution Non-Commercial Licence ( which permits unrestricted non-commercial use, distribution and reproduction in any medium, provided the original work is properly cited.
Publication Status: Published
Appears in Collections:Clinical Sciences
Molecular Sciences
Faculty of Medicine

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