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Fission yeast SWI/SNF and RSC complexes show compositional and functional differences from budding yeast.

Title: Fission yeast SWI/SNF and RSC complexes show compositional and functional differences from budding yeast.
Authors: Monahan, BJ
Villén, J
Marguerat, S
Bähler, J
Gygi, SP
Winston, F
Item Type: Journal Article
Abstract: SWI/SNF chromatin-remodeling complexes have crucial roles in transcription and other chromatin-related processes. The analysis of the two members of this class in Saccharomyces cerevisiae, SWI/SNF and RSC, has heavily contributed to our understanding of these complexes. To understand the in vivo functions of SWI/SNF and RSC in an evolutionarily distant organism, we have characterized these complexes in Schizosaccharomyces pombe. Although core components are conserved between the two yeasts, the compositions of S. pombe SWI/SNF and RSC differ from their S. cerevisiae counterparts and in some ways are more similar to metazoan complexes. Furthermore, several of the conserved proteins, including actin-like proteins, are markedly different between the two yeasts with respect to their requirement for viability. Finally, phenotypic and microarray analyses identified widespread requirements for SWI/SNF and RSC on transcription including strong evidence that SWI/SNF directly represses iron-transport genes.
Issue Date: 11-Jul-2008
URI: http://hdl.handle.net/10044/1/21978
DOI: https://dx.doi.org/10.1038/nsmb.1452
ISSN: 1545-9993
Publisher: Nature Publishing Group
Start Page: 873
End Page: 880
Journal / Book Title: Nature Structural & Molecular Biology
Volume: 15
Issue: 8
Copyright Statement: © 2008 Nature Publishing Group Nature Structural & Molecular Biology 15, 873 - 880 (2008). http://www.nature.com/nsmb/journal/v15/n8/full/nsmb.1452.html
Publication Status: Published
Conference Place: United States
Appears in Collections:Clinical Sciences
Molecular Sciences
Faculty of Medicine



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