Immune reconstitution inflammatory syndrome in HIV-infected patients

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Title: Immune reconstitution inflammatory syndrome in HIV-infected patients
Authors: Walker, NF
Scriven, J
Meintjes, G
Wilkinson, RJ
Item Type: Journal Article
Abstract: Access to antiretroviral therapy (ART) is improving worldwide. Immune reconstitution inflammatory syndrome (IRIS) is a common complication of ART initiation. In this review, we provide an overview of clinical and epidemiological features of HIV-associated IRIS, current understanding of pathophysiological mechanisms, available therapy, and preventive strategies. The spectrum of HIV-associated IRIS is described, with a particular focus on three important pathogen-associated forms: tuberculosis-associated IRIS, cryptococcal IRIS, and Kaposis sarcoma IRIS. While the clinical features and epidemiology are well described, there are major gaps in our understanding of pathophysiology and as a result therapeutic and preventative strategies are suboptimal. Timing of ART initiation is critical to reduce IRIS-associated morbidity. Improved understanding of the pathophysiology of IRIS will hopefully enable improved diagnostic modalities and better targeted treatments to be developed.
Issue Date: 12-Feb-2015
Date of Acceptance: 26-Jun-2014
ISSN: 1179-1373
Publisher: Dove Medical Press
Start Page: 49
End Page: 64
Journal / Book Title: HIV/AIDS - Research and Palliative Care
Volume: 7
Copyright Statement: © 2015 Dove Medical Press. This work is published by Dove Medical Press Limited, and licensed under Creative Commons Attribution - Non Commercial (unported, v3.0) License. The full terms of the License are available at Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. Permissions beyond the scope of the License are administered by Dove Medical Press Limited. Information on how to request permission may be found at:
Appears in Collections:Department of Medicine

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