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Developments in the tools and methodologies of synthetic biology.

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Title: Developments in the tools and methodologies of synthetic biology.
Author(s): Kelwick, R
MacDonald, JT
Webb, AJ
Freemont, P
Item Type: Journal Article
Abstract: Synthetic biology is principally concerned with the rational design and engineering of biologically based parts, devices, or systems. However, biological systems are generally complex and unpredictable, and are therefore, intrinsically difficult to engineer. In order to address these fundamental challenges, synthetic biology is aiming to unify a body of knowledge from several foundational scientific fields, within the context of a set of engineering principles. This shift in perspective is enabling synthetic biologists to address complexity, such that robust biological systems can be designed, assembled, and tested as part of a biological design cycle. The design cycle takes a forward-design approach in which a biological system is specified, modeled, analyzed, assembled, and its functionality tested. At each stage of the design cycle, an expanding repertoire of tools is being developed. In this review, we highlight several of these tools in terms of their applications and benefits to the synthetic biology community.
Publication Date: 26-Nov-2014
URI: http://hdl.handle.net/10044/1/19609
DOI: http://dx.doi.org/10.3389/fbioe.2014.00060
Start Page: 60
Journal / Book Title: Front Bioeng Biotechnol
Volume: 2
Copyright Statement: © 2014 Kelwick, MacDonald, Webb and Freemont. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
Conference Place: Switzerland
Appears in Collections:Department of Medicine
Faculty of Natural Sciences



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