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New loci associated with kidney function and chronic kidney disease.

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Title: New loci associated with kidney function and chronic kidney disease.
Authors: Köttgen, A
Pattaro, C
Böger, CA
Fuchsberger, C
Olden, M
Glazer, NL
Parsa, A
Gao, X
Yang, Q
Smith, AV
O'Connell, JR
Li, M
Schmidt, H
Tanaka, T
Isaacs, A
Ketkar, S
Hwang, SJ
Johnson, AD
Dehghan, A
Teumer, A
Paré, G
Atkinson, EJ
Zeller, T
Lohman, K
Cornelis, MC
Probst-Hensch, NM
Kronenberg, F
Tönjes, A
Hayward, C
Aspelund, T
Eiriksdottir, G
Launer, LJ
Harris, TB
Rampersaud, E
Mitchell, BD
Arking, DE
Boerwinkle, E
Struchalin, M
Cavalieri, M
Singleton, A
Giallauria, F
Metter, J
de Boer, IH
Haritunians, T
Lumley, T
Siscovick, D
Psaty, BM
Zillikens, MC
Oostra, BA
Feitosa, M
Province, M
de Andrade, M
Turner, ST
Schillert, A
Ziegler, A
Wild, PS
Schnabel, RB
Wilde, S
Munzel, TF
Leak, TS
Illig, T
Klopp, N
Meisinger, C
Wichmann, HE
Koenig, W
Zgaga, L
Zemunik, T
Kolcic, I
Minelli, C
Hu, FB
Johansson, A
Igl, W
Zaboli, G
Wild, SH
Wright, AF
Campbell, H
Ellinghaus, D
Schreiber, S
Aulchenko, YS
Felix, JF
Rivadeneira, F
Uitterlinden, AG
Hofman, A
Imboden, M
Nitsch, D
Brandstätter, A
Kollerits, B
Kedenko, L
Mägi, R
Stumvoll, M
Kovacs, P
Boban, M
Campbell, S
Endlich, K
Völzke, H
Kroemer, HK
Nauck, M
Völker, U
Polasek, O
Vitart, V
Badola, S
Parker, AN
Ridker, PM
Kardia, SL
Blankenberg, S
Liu, Y
Curhan, GC
Franke, A
Rochat, T
Paulweber, B
Prokopenko, I
Wang, W
Gudnason, V
Shuldiner, AR
Coresh, J
Schmidt, R
Ferrucci, L
Shlipak, MG
van Duijn, CM
Borecki, I
Krämer, BK
Rudan, I
Gyllensten, U
Wilson, JF
Witteman, JC
Pramstaller, PP
Rettig, R
Hastie, N
Chasman, DI
Kao, WH
Heid, IM
Fox, CS
Item Type: Journal Article
Abstract: Chronic kidney disease (CKD) is a significant public health problem, and recent genetic studies have identified common CKD susceptibility variants. The CKDGen consortium performed a meta-analysis of genome-wide association data in 67,093 individuals of European ancestry from 20 predominantly population-based studies in order to identify new susceptibility loci for reduced renal function as estimated by serum creatinine (eGFRcrea), serum cystatin c (eGFRcys) and CKD (eGFRcrea 60 ml/min/1.73 m 2; n = 5,807 individuals with CKD (cases)). Follow-up of the 23 new genome-wide-significant loci (P 5 × 10 8) in 22,982 replication samples identified 13 new loci affecting renal function and CKD (in or near LASS2, GCKR, ALMS1, TFDP2, DAB2, SLC34A1, VEGFA, PRKAG2, PIP5K1B, ATXN2, DACH1, UBE2Q2 and SLC7A9) and 7 loci suspected to affect creatinine production and secretion (CPS1, SLC22A2, TMEM60, WDR37, SLC6A13, WDR72 and BCAS3). These results further our understanding of the biologic mechanisms of kidney function by identifying loci that potentially influence nephrogenesis, podocyte function, angiogenesis, solute transport and metabolic functions of the kidney. © 2010 Nature America, Inc. All rights reserved.
Issue Date: 1-May-2010
URI: http://hdl.handle.net/10044/1/19324
DOI: http://dx.doi.org/10.1038/ng.568
Start Page: 376
End Page: 384
Journal / Book Title: Nat Genet
Volume: 42
Issue: 5
Copyright Statement: © 2010, Rights Managed by Nature Publishing Group
Conference Place: United States
Appears in Collections:Population Genetics and Gene Therapy
Infectious Disease Epidemiology
Epidemiology, Public Health and Primary Care



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