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HMG-coenzyme A reductase inhibition, type 2 diabetes, and bodyweight: evidence from genetic analysis and randomised trials

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Title: HMG-coenzyme A reductase inhibition, type 2 diabetes, and bodyweight: evidence from genetic analysis and randomised trials
Authors: Swerdlow, DI
Preiss, D
Kuchenbaecker, KB
Holmes, MV
Engmann, JEL
Shah, T
Sofat, R
Stender, S
Johnson, PCD
Scott, RA
Leusink, M
Verweij, N
Sharp, SJ
Guo, Y
Giambartolomei, C
Chung, C
Peasey, A
Amuzu, A
Li, K
Palmen, J
Howard, P
Cooper, JA
Drenos, F
Li, YR
Lowe, G
Gallacher, J
Stewart, MCW
Tzoulaki, I
Buxbaum, SG
Daphne, LVDA
Forouhi, NG
Onland-Moret, NC
Van der Schouw, YT
Schnabel, RB
Hubacek, JA
Kubinova, R
Baceviciene, M
Tamosiunas, A
Pajak, A
Topor-Madry, R
Stepaniak, U
Malyutina, SA
Baldassarre, D
Sennblad, B
Tremoli, E
De Faire, U
Veglia, F
Ford, I
Jukema, JW
Westendorp, RGJ
De Borst, GJ
De Jong, PA
Algra, A
Spiering, W
Maitland-van der Zee, AH
Klungel, OH
De Boer, A
Doevendans, PA
Eaton, CB
Robinson, JG
Duggan, D
Kjekshus, J
Downs, JR
Gotto, AM
Keech, AC
Marchioli, R
Tognoni, G
Sever, PS
Poulter, NR
Waters, DD
Pedersen, TR
Amarenco, P
Nakamura, H
McMurray, JJV
Lewsey, JD
Chasman, DI
Ridker, PM
Maggioni, AP
Tavazzi, L
Ray, KK
Seshasai, SRK
Manson, JE
Price, JF
Whincup, PH
Morris, RW
Lawlor, DA
Smith, GD
Ben-Shlomo, Y
Schreiner, PJ
Fornage, M
Siscovick, DS
Cushman, M
Kumari, M
Wareham, NJ
Verschuren, WMM
Redline, S
Patel, SR
Whittaker, JC
Hamsten, A
Delaney, JA
Dale, C
Gaunt, TR
Wong, A
Kuh, D
Hardy, R
Kathiresan, S
Castillo, BA
Van der Harst, P
Brunner, EJ
Tybjaerg-Hansen, A
Marmot, MG
Krauss, RM
Tsai, M
Coresh, J
Hoogeveen, RC
Psaty, BM
Lange, LA
Hakonarson, H
Dudbridge, F
Humphries, SE
Talmud, PJ
Kivimaeki, M
Timpson, NJ
Langenberg, C
Asselbergs, FW
Voevoda, M
Bobak, M
Pikhart, H
Wilson, JG
Reiner, AP
Keating, BJ
Hingorani, AD
Sattar, N
Item Type: Journal Article
Issue Date: 24-Jan-2015
Date of Acceptance: 24-Sep-2014
URI: http://hdl.handle.net/10044/1/18237
DOI: https://dx.doi.org/10.1016/S0140-6736(14)61183-1
ISSN: 1474-547X
Publisher: Elsevier: Lancet
Start Page: 351
End Page: 361
Journal / Book Title: Lancet
Volume: 385
Issue: 9965
Copyright Statement: © Swerdlow et al. Open Access article distributed under the terms of CC BY
Sponsor/Funder: Imperial College Healthcare NHS Trust- BRC Funding
National Institute for Health Research
Funder's Grant Number: RDC02 79560
n/a
Keywords: Science & Technology
Life Sciences & Biomedicine
Medicine, General & Internal
General & Internal Medicine
HIGH-DOSE ATORVASTATIN
BODY-MASS INDEX
STATIN THERAPY
MENDELIAN RANDOMIZATION
ASSOCIATION ANALYSES
LDL CHOLESTEROL
METAANALYSIS
RISK
PREVENTION
DISEASE
Aged
Body Mass Index
Body Weight
Cholesterol, HDL
Cholesterol, LDL
Diabetes Mellitus, Type 2
Female
Genetic Testing
Humans
Hydroxymethylglutaryl CoA Reductases
Hydroxymethylglutaryl-CoA Reductase Inhibitors
Male
Middle Aged
Polymorphism, Single Nucleotide
Randomized Controlled Trials as Topic
Risk Factors
DIAGRAM Consortium
MAGIC Consortium
InterAct Consortium
11 Medical And Health Sciences
Publication Status: Published
Open Access location: https://dx.doi.org/10.1016/S0140-6736(14)61183-1
Appears in Collections:National Heart and Lung Institute
Department of Medicine
Faculty of Medicine
Epidemiology, Public Health and Primary Care



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