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β-adrenergic receptor responsiveness in aging heart and clinical implications.

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Title: β-adrenergic receptor responsiveness in aging heart and clinical implications.
Author(s): Ferrara, N
Komici, K
Corbi, G
Pagano, G
Furgi, G
Rengo, C
Femminella, GD
Leosco, D
Bonaduce, D
Item Type: Journal Article
Abstract: Elderly healthy individuals have a reduced exercise tolerance and a decreased left ventricle inotropic reserve related to increased vascular afterload, arterial-ventricular load mismatching, physical deconditioning and impaired autonomic regulation (the so called β-adrenergic desensitization ). Adrenergic responsiveness is altered with aging and the age-related changes are limited to the β-adrenergic receptor density reduction and to the β-adrenoceptor-G-protein(s)-adenylyl cyclase system abnormalities, while the type and level of abnormalities change with species and tissues. Epidemiological studies have shown an high incidence and prevalence of heart failure in the elderly and a great body of evidence correlate the changes of β-adrenergic system with heart failure pathogenesis. In particular it is well known that: (a) levels of cathecolamines are directly correlated with mortality and functional status in heart failure, (b) β1-adrenergic receptor subtype is down-regulated in heart failure, (c) heart failure-dependent cardiac adrenergic responsiveness reduction is related to changes in G proteins activity. In this review we focus on the cardiovascular β-adrenergic changes involvement in the aging process and on similarities and differences between aging heart and heart failure. © 2014 Ferrara, Komici, Corbi, Pagano, Furgi, Rengo, Femminella, Leosco and Bonaduce.
Publication Date: 12-Feb-2014
URI: http://hdl.handle.net/10044/1/14609
DOI: http://dx.doi.org/10.3389/fphys.2013.00396
Start Page: 396
Journal / Book Title: Front Physiol
Volume: 4
Copyright Statement: Copyright © 2014 Ferrara, Komici, Corbi, Pagano, Furgi, Rengo, Femminella, Leosco and Bonaduce. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these term
Conference Place: Switzerland
Appears in Collections:Faculty of Medicine



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