Characterization of skeletal phenotypes of TRalpha1 and TRbeta mutant mice: implications for tissue thyroid status and T3 target gene expression.

Title: Characterization of skeletal phenotypes of TRalpha1 and TRbeta mutant mice: implications for tissue thyroid status and T3 target gene expression.
Authors: O'Shea, PJ
Bassett, JH
Cheng, SY
Williams, GR
Item Type: Journal Article
Abstract: Bone development is extremely sensitive to alterations in thyroid status. Recently, we analyzed the skeletal phenotypes of mice with the dominant negative resistance to thyroid hormone (RTH) mutation PV targeted to either the thyroid hormone receptor (TR) alpha1 or beta gene. This perspective summarizes our findings to date and explores the wider implications for thyroid status and T3 target gene expression in individual tissues.
Issue Date: 31-Jan-2006
URI: http://hdl.handle.net/10044/1/12801
DOI: http://dx.doi.org/10.1621/nrs.04011
Start Page: e011
Journal / Book Title: Nucl Recept Signal
Volume: 4
Copyright Statement: Copyright © 2006, O'Shea et al. This is an open-access article distributed under the terms of the Creative Commons Non-Commercial Attribution License, which permits unrestricted non-commercial use distribution and reproduction in any medium, provided the original work is properly cited.
Conference Place: United States
Appears in Collections:Faculty of Medicine



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