Glanzmann, BrigitteBrigitteGlanzmannJooste, TracyTracyJoosteGhoor, SamiraSamiraGhoorGordon, RichardRichardGordonMia, RizwanaRizwanaMiaMao, JunJunMaoLi, HaoHaoLiCharls, PatrickPatrickCharlsDouman, CraigCraigDoumanKotze, Maritha JMaritha JKotzePeeters, Armand VArmand VPeetersLoots, GlaudinaGlaudinaLootsEsser, MonicaMonicaEsserTiemessen, Caroline TCaroline TTiemessenWilkinson, Robert JRobert JWilkinsonLouw, JohanJohanLouwGray, GlendaGlendaGrayWarren, Robin MRobin MWarrenMoller, MarloMarloMollerKinnear, CraigCraigKinnear2020-12-162021-01-12Scientific Reports, 2021, 11 (606), pp.1-82045-2322http://hdl.handle.net/10044/1/85027The advent and evolution of next generation sequencing has considerably impacted genomic research. Until recently, South African researchers were unable to access affordable platforms capable of human whole genome sequencing locally and DNA samples had to be exported. Here we report the whole genome sequences of the first six human DNA samples sequenced and analysed at the South African Medical Research Council’s Genomics Centre. We demonstrate that the data obtained is of high quality, with an average sequencing depth of 36.41, and that the output is comparable to data generated internationally on a similar platform. The Genomics Centre creates an environment where African researchers are able to access world class facilities, increasing local capacity to sequence whole genomes as well as store and analyse the data.© The Author(s) 2021. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. Te images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.Journal Articlehttps://www.dx.doi.org/10.1038/s41598-020-79794-xhttps://www.nature.com/articles/s41598-020-79794-x104803/Z/14/ZWDAI_P83556