Gudmundsson, SannaSannaGudmundssonKarczewski, Konrad JKonrad JKarczewskiFrancioli, Laurent CLaurent CFrancioliTiao, GraceGraceTiaoCummings, Beryl BBeryl BCummingsAlfoldi, JessicaJessicaAlfoldiWang, QingboQingboWangCollins, Ryan LRyan LCollinsLaricchia, Kristen MKristen MLaricchiaGanna, AndreaAndreaGannaBirnbaum, Daniel PDaniel PBirnbaumGauthier, Laura DLaura DGauthierBrand, HarrisonHarrisonBrandSolomonson, MatthewMatthewSolomonsonWatts, Nicholas ANicholas AWattsRhodes, DanielDanielRhodesSinger-Berk, MorielMorielSinger-BerkEngland, Eleina MEleina MEnglandSeaby, Eleanor GEleanor GSeabyKosmicki, Jack AJack AKosmickiWalters, Raymond KRaymond KWaltersTashman, KatherineKatherineTashmanFarjoun, YossiYossiFarjounBanks, EricEricBanksPoterba, TimothyTimothyPoterbaWang, ArcturusArcturusWangSeed, CottonCottonSeedWhiffin, NicolaNicolaWhiffinChong, Jessica XJessica XChongSamocha, Kaitlin EKaitlin ESamochaPierce-Hoffman, EmmaEmmaPierce-HoffmanZappala, ZacharyZacharyZappalaO'Donnell-Luria, Anne HAnne HO'Donnell-LuriaMinikel, Eric VallabhEric VallabhMinikelWeisburd, BenBenWeisburdLek, MonkolMonkolLekWare, James SJames SWareVittal, ChristopherChristopherVittalArmean, Irina MIrina MArmeanBergelson, LouisLouisBergelsonCibulskis, KristianKristianCibulskisConnolly, Kristen MKristen MConnollyCovarrubias, MiguelMiguelCovarrubiasDonnelly, StaceyStaceyDonnellyFerriera, StevenStevenFerrieraGabriel, StaceyStaceyGabrielGentry, JeffJeffGentryGupta, NamrataNamrataGuptaJeandet, ThibaultThibaultJeandetKaplan, DianeDianeKaplanLlanwarne, ChristopherChristopherLlanwarneMunshi, RuchiRuchiMunshiNovod, SamSamNovodPetrillo, NikelleNikellePetrilloRoazen, DavidDavidRoazenRuano-Rubio, ValentinValentinRuano-RubioSaltzman, AndreaAndreaSaltzmanSchleicher, MollyMollySchleicherSoto, JoseJoseSotoTibbetts, KathleenKathleenTibbettsTolonen, CharlotteCharlotteTolonenWade, GordonGordonWadeTalkowski, Michael EMichael ETalkowskiNeale, Benjamin MBenjamin MNealeDaly, Mark JMark JDalyMacArthur, Daniel GDaniel GMacArthur2022-03-082022-03-082021-08-09Nature, 2021, 597 (7874), pp.E3-E40028-0836http://hdl.handle.net/10044/1/95288© 2020 The Author(s). Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.Science & TechnologyMultidisciplinary SciencesScience & Technology - Other TopicsOF-FUNCTION VARIANTSJournal Articlehttps://www.dx.doi.org/10.1038/s41586-021-03758-yhttps://www.nature.com/articles/s41586-021-03758-y1476-4687