Induction of innate cytokine responses by respiratory mucosal challenge with R848 in zebrafish, mice and humans

Progatzky, FränzeFränzeProgatzkyJha, AkhileshAkhileshJhaWane, MadinaMadinaWaneThwaites, Ryan SRyan SThwaitesMakris, SpyridonSpyridonMakrisShattock, Robin JRobin JShattockJohansson, CeciliaCeciliaJohanssonOpenshaw, Peter JPeter JOpenshawBugeon, LaurenceLaurenceBugeonHansel, Trevor TTrevor THanselDallman, Margaret JMargaret JDallman2019-05-302019-07-01Journal of Allergy and Clinical Immunology, 2019, 144 (1), pp.342-345.e70091-6749http://hdl.handle.net/10044/1/70073We compared live zebrafish, mouse and human nasal challenge responses to the TLR7/8 agonist resiquimod (R848). We found remarkably similar induction of mediators in the three species, offering novel mucosal models of innate anti-viral immunity.© 2019 The Authors. Published by Elsevier Inc. on behalf of the American Academy of Allergy, Asthma & Immunology. This is an open access article under the CC BY li-cense (http://creativecommons.org/licenses/by/4.0/)comparative cross-species analysismucosal innate immunitynasal respiratory mucosaresiquimodvaccine adjuvantsInduction of innate cytokine responses by respiratory mucosal challenge with R848 in zebrafish, mice and humansJournal Articlehttps://www.dx.doi.org/10.1016/j.jaci.2019.04.003P45058RDA02MR/R005982/1MR/R005982/1NF-SI-0513-10150RDA06 79560A4421097-6825