Dong, CatherineCatherineDongChan, Simon SMSimon SMChanJantchou, PrevostPrevostJantchouRacine, AntoineAntoineRacineOldenburg, BasBasOldenburgWeiderpass, ElisabeteElisabeteWeiderpassHeath, Alicia KAlicia KHeathTong, Tammy YNTammy YNTongTjønneland, AnneAnneTjønnelandKyrø, CecilieCecilieKyrøde Mesquita, Bas BuenoBas Buenode MesquitaKaaks, RudolfRudolfKaaksKatzke, Verena AVerena AKatzkeBergman, Manuela MManuela MBergmanBoeing, HeinerHeinerBoeingPalli, DomenicoDomenicoPalliMasala, GiovannaGiovannaMasalaTumino, RosarioRosarioTuminoSacerdote, CarlottaCarlottaSacerdoteColorado-Yohar, Sandra MSandra MColorado-YoharSánchez, Maria-JoseMaria-JoseSánchezGrip, OlofOlofGripLindgren, StefanStefanLindgrenLuben, RobertRobertLubenHuybrechts, IngeIngeHuybrechtsGunter, Marc JMarc JGunterMahamat-Saleh, YahyaYahyaMahamat-SalehBoutron-Ruault, Marie-ChristineMarie-ChristineBoutron-RuaultCarbonnel, FranckFranckCarbonnel2022-04-282023-04-082022-08Journal of Crohns & Colitis, 2022, 16 (8), pp.1187-11961873-9946http://hdl.handle.net/10044/1/96483BACKGROUND AND AIMS: We aimed to investigate the association between protein intake and risk of inflammatory bowel disease (IBD) in the European Prospective Investigation into Cancer and Nutrition. METHODS: 413 593 participants from eight European countries were included. Dietary data were collected at baseline from validated food frequency questionnaires. Dietary data were calibrated to correct errors of measures related to each country-specific questionnaire. Associations between proteins (total, animal, and vegetable) or food sources of animal proteins, and IBD risk were estimated by Cox proportional hazard models. RESULTS: After a mean follow-up of 16 years, 177 patients with Crohn's disease (CD) and 418 with ulcerative colitis (UC), were identified. There was no association between total protein, animal, or vegetable protein intakes and CD or UC risks. Total meat and red meat intakes were associated with UC risk (HR for the 4 thvs. 1 st quartile = 1.40; 95% CI = 0.99-1.98; P-trend = 0.01; and 1.61; 95% CI = 1.10-2.36, P-trend = 0.007, respectively). There was no association between other food sources of animal protein (processed meat, fish, shellfish, eggs, poultry) and UC. We found no association between food sources of animal proteins and CD risk. CONCLUSION: Meat and red meat consumptions are associated with higher risks of UC. These results support dietary counseling of low meat intake in people at high-risk of IBD.© The Author(s) 2022. Published by Oxford University Press on behalf of European Crohn’s and Colitis Organisation. All rights reserved. For permissions, please email: journals.permissions@oup.com This article is published and distributed under the terms of the Oxford University Press, Standard Journals Publication Model (https://academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model)Dietinflammatory bowel diseasemeatJournal Articlehttps://www.dx.doi.org/10.1093/ecco-jcc/jjac054https://academic.oup.com/ecco-jcc/advance-article-abstract/doi/10.1093/ecco-jcc/jjac054/6565743?redirectedFrom=fulltext1876-4479