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Tracking the incidence and risk factors for SARS-CoV-2 infection using historical maternal booking serum samples

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Title: Tracking the incidence and risk factors for SARS-CoV-2 infection using historical maternal booking serum samples
Authors: Mullins, E
McCabe, R
Bird, SM
Randell, P
Pond, MJ
Regan, L
Parker, E
McClure, M
Donnelly, CA
Item Type: Journal Article
Abstract: The early transmission dynamics of SARS-CoV-2 in the UK are unknown but their investigation is critical to aid future pandemic planning. We tested over 11,000 anonymised, stored historic antenatal serum samples, given at two north-west London NHS trusts in 2019 and 2020, for total antibody to SARS-CoV-2 receptor binding domain (anti-RBD). Estimated prevalence of seroreactivity increased from 1% prior to mid-February 2020 to 17% in September 2020. Our results show higher prevalence of seroreactivity to SARS-CoV-2 in younger, non-white ethnicity, and more deprived groups. We found no significant interaction between the effects of ethnicity and deprivation. Derived from prevalence, the estimated incidence of seroreactivity reflects the trends observed in daily hospitalisations and deaths in London that followed 10 and 13 days later, respectively. We quantified community transmission of SARS-CoV-2 in London, which peaked in late March / early April 2020 with no evidence of community transmission until after January 2020. Our study was not able to determine the date of introduction of the SARS-CoV-2 virus but demonstrates the value of stored antenatal serum samples as a resource for serosurveillance during future outbreaks.
Date of Acceptance: 1-Sep-2022
URI: http://hdl.handle.net/10044/1/99472
DOI: 10.1371/journal.pone.0273966
ISSN: 1932-6203
Publisher: Public Library of Science (PLoS)
Start Page: e0273966
End Page: e0273966
Journal / Book Title: PLoS One
Volume: 17
Issue: 9
Copyright Statement: © 2022 Mullins et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Sponsor/Funder: Community Jameel Imperial College COVID-19 Excellence Fund
Funder's Grant Number: n/a
Keywords: General Science & Technology
Publication Status: Published online
Open Access location: https://journals.plos.org/plosone/article/authors?id=10.1371/journal.pone.0273966
Online Publication Date: 2022-09-02
Appears in Collections:Department of Metabolism, Digestion and Reproduction
Imperial College London COVID-19

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