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Imaging in patients with glioblastoma: A national cohort study

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Title: Imaging in patients with glioblastoma: A national cohort study
Authors: Dumba, M
Fry, A
Shelton, J
Booth, TC
Jones, B
Shuaib, H
Williams, M
Item Type: Journal Article
Abstract: Background Glioblastoma is the most common malignant brain tumor in adults and has a poor prognosis. This cohort of patients is diverse and imaging is vital to formulate treatment plans. Despite this, there is relatively little data on patterns of use of imaging and imaging workload in routine practice. Methods We examined imaging patterns for all patients aged 15–99 years resident in England who were diagnosed with a glioblastoma between 1st January 2013 and 31st December 2014. Patients without imaging and death-certificate-only registrations were excluded. Results The analytical cohort contained 4,307 patients. There was no significant variation in pre- or postdiagnostic imaging practice by sex or deprivation quintile. Postdiagnostic imaging practice was varied. In the group of patients who were treated most aggressively (surgical debulking and chemoradiation) and were MRI compatible, only 51% had a postoperative MRI within 72 hours of surgery. In patients undergoing surgery who subsequently received radiotherapy, only 61% had a postsurgery and preradiotherapy MRI. Conclusions Prediagnostic imaging practice is uniform. Postdiagnostic imaging practice was variable. With increasing evidence and clearer recommendations regarding debulking surgery and planning radiotherapy imaging, the reason for this is unclear and will form the basis of further work.
Issue Date: Dec-2022
Date of Acceptance: 1-Jun-2022
URI: http://hdl.handle.net/10044/1/99384
DOI: 10.1093/nop/npac048
ISSN: 2054-2585
Publisher: Oxford University Press
Start Page: 487
End Page: 495
Journal / Book Title: Neuro-Oncology Practice
Volume: 9
Issue: 6
Copyright Statement: © The Author(s) 2022. Published by Oxford University Press on behalf of the Society for Neuro-Oncology and the European Association of Neuro-Oncology. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
Sponsor/Funder: Imperial College Healthcare NHS Trust- BRC Funding
Cancer Research UK
Funder's Grant Number: RDB01 79560
27434
Keywords: Science & Technology
Life Sciences & Biomedicine
Clinical Neurology
Neurosciences & Neurology
glioblastoma
imaging
outcomes
radiotherapy
surgery
UNITED-STATES
PRIMARY BRAIN
TEMOZOLOMIDE
SURVIVAL
TUMORS
ADULT
MULTIFORME
GUIDELINE
CANCER
glioblastoma
imaging
outcomes
radiotherapy
surgery
Science & Technology
Life Sciences & Biomedicine
Clinical Neurology
Neurosciences & Neurology
glioblastoma
imaging
outcomes
radiotherapy
surgery
UNITED-STATES
PRIMARY BRAIN
TEMOZOLOMIDE
SURVIVAL
TUMORS
ADULT
MULTIFORME
GUIDELINE
CANCER
Publication Status: Published
Online Publication Date: 2022-06-11
Appears in Collections:Department of Surgery and Cancer
Faculty of Medicine



This item is licensed under a Creative Commons License Creative Commons