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Highly effective liquid and solid phase extraction methods to concentrate radioiodine isotopes for radioiodination chemistry
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Title: | Highly effective liquid and solid phase extraction methods to concentrate radioiodine isotopes for radioiodination chemistry |
Authors: | Davis, C Li, C Nie, R Guzzardi, N Dworakowska, B Sadasivam, P Maher, J Aboagye, EO Lu, Z Yan, R |
Item Type: | Journal Article |
Abstract: | Radioactive iodine isotopes play a pivotal role in radiopharmaceuticals. Large-scale production of multi-patient dose of radioiodinated nuclear medicines requires high concentration of radioiodine. We demonstrate that tetrabutylammonium chloride and methyltrioctylamonium chloride are effective phase transfer reagents to concentrate iodide-124, iodide-125 and iodide-131 from the corresponding commercial water solutions. The resulting concentrated radioiodide, in the presence of either phase transfer reagent, does not hamper the chemical reactivity of aqueous radioiodide in the copper (II)-mediated one-pot three-component click chemistry to produce radioiodinated iodotriazoles. |
Issue Date: | Aug-2022 |
Date of Acceptance: | 25-Jul-2022 |
URI: | http://hdl.handle.net/10044/1/99161 |
DOI: | 10.1002/jlcr.3994 |
ISSN: | 0362-4803 |
Publisher: | Wiley |
Start Page: | 280 |
End Page: | 287 |
Journal / Book Title: | Journal of Labelled Compounds and Radiopharmaceuticals |
Volume: | 65 |
Issue: | 10-11 |
Copyright Statement: | © 2022 The Authors. Journal of Labelled Compounds and Radiopharmaceuticals published by John Wiley & Sons Ltd. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
Sponsor/Funder: | Imperial College Healthcare NHS Trust- BRC Funding |
Funder's Grant Number: | RDC04 |
Keywords: | Science & Technology Life Sciences & Biomedicine Physical Sciences Biochemical Research Methods Chemistry, Medicinal Chemistry, Analytical Biochemistry & Molecular Biology Pharmacology & Pharmacy Chemistry iodotriazole phase transfer reagent radioiodination radioiodine REAGENT iodotriazole phase transfer reagent radioiodination radioiodine Chlorides Copper Humans Iodides Iodine Radioisotopes Radiopharmaceuticals Solid Phase Extraction Thyroid Neoplasms Water Humans Thyroid Neoplasms Chlorides Iodides Copper Water Iodine Radioisotopes Radiopharmaceuticals Solid Phase Extraction iodotriazole phase transfer reagent radioiodination radioiodine 0305 Organic Chemistry 1115 Pharmacology and Pharmaceutical Sciences Medicinal & Biomolecular Chemistry |
Publication Status: | Published |
Conference Place: | England |
Online Publication Date: | 2022-07-29 |
Appears in Collections: | Department of Surgery and Cancer Faculty of Medicine |
This item is licensed under a Creative Commons License