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Highly effective liquid and solid phase extraction methods to concentrate radioiodine isotopes for radioiodination chemistry

Title: Highly effective liquid and solid phase extraction methods to concentrate radioiodine isotopes for radioiodination chemistry
Authors: Davis, C
Li, C
Nie, R
Guzzardi, N
Dworakowska, B
Sadasivam, P
Maher, J
Aboagye, EO
Lu, Z
Yan, R
Item Type: Journal Article
Abstract: Radioactive iodine isotopes play a pivotal role in radiopharmaceuticals. Large-scale production of multi-patient dose of radioiodinated nuclear medicines requires high concentration of radioiodine. We demonstrate that tetrabutylammonium chloride and methyltrioctylamonium chloride are effective phase transfer reagents to concentrate iodide-124, iodide-125 and iodide-131 from the corresponding commercial water solutions. The resulting concentrated radioiodide, in the presence of either phase transfer reagent, does not hamper the chemical reactivity of aqueous radioiodide in the copper (II)-mediated one-pot three-component click chemistry to produce radioiodinated iodotriazoles.
Issue Date: Aug-2022
Date of Acceptance: 25-Jul-2022
URI: http://hdl.handle.net/10044/1/99161
DOI: 10.1002/jlcr.3994
ISSN: 0362-4803
Publisher: Wiley
Start Page: 280
End Page: 287
Journal / Book Title: Journal of Labelled Compounds and Radiopharmaceuticals
Volume: 65
Issue: 10-11
Copyright Statement: © 2022 The Authors. Journal of Labelled Compounds and Radiopharmaceuticals published by John Wiley & Sons Ltd. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
Sponsor/Funder: Imperial College Healthcare NHS Trust- BRC Funding
Funder's Grant Number: RDC04
Keywords: Science & Technology
Life Sciences & Biomedicine
Physical Sciences
Biochemical Research Methods
Chemistry, Medicinal
Chemistry, Analytical
Biochemistry & Molecular Biology
Pharmacology & Pharmacy
Chemistry
iodotriazole
phase transfer reagent
radioiodination
radioiodine
REAGENT
iodotriazole
phase transfer reagent
radioiodination
radioiodine
Chlorides
Copper
Humans
Iodides
Iodine Radioisotopes
Radiopharmaceuticals
Solid Phase Extraction
Thyroid Neoplasms
Water
Humans
Thyroid Neoplasms
Chlorides
Iodides
Copper
Water
Iodine Radioisotopes
Radiopharmaceuticals
Solid Phase Extraction
iodotriazole
phase transfer reagent
radioiodination
radioiodine
0305 Organic Chemistry
1115 Pharmacology and Pharmaceutical Sciences
Medicinal & Biomolecular Chemistry
Publication Status: Published
Conference Place: England
Online Publication Date: 2022-07-29
Appears in Collections:Department of Surgery and Cancer
Faculty of Medicine



This item is licensed under a Creative Commons License Creative Commons