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Polymeric carriers for delivery of RNA cancer therapeutics

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Title: Polymeric carriers for delivery of RNA cancer therapeutics
Authors: Mirón-Barroso, S
Correia, JS
Frampton, AE
Lythgoe, MP
Clark, J
Tookman, L
Ottaviani, S
Castellano, L
Porter, AE
Georgiou, TK
Krell, J
Item Type: Journal Article
Abstract: As research uncovers the underpinnings of cancer biology, new targeted therapies have been developed. Many of these therapies are small molecules, such as kinase inhibitors, that target specific proteins; however, only 1% of the genome encodes for proteins and only a subset of these proteins has ‘druggable’ active binding sites. In recent decades, RNA therapeutics have gained popularity due to their ability to affect targets that small molecules cannot. Additionally, they can be manufactured more rapidly and cost-effectively than small molecules or recombinant proteins. RNA therapeutics can be synthesised chemically and altered quickly, which can enable a more personalised approach to cancer treatment. Even though a wide range of RNA therapeutics are being developed for various indications in the oncology setting, none has reached the clinic to date. One of the main reasons for this is attributed to the lack of safe and effective delivery systems for this type of therapeutic. This review focuses on current strategies to overcome these challenges and enable the clinical utility of these novel therapeutic agents in the cancer clinic.
Issue Date: 2-Aug-2022
Date of Acceptance: 25-Jul-2022
URI: http://hdl.handle.net/10044/1/99089
DOI: 10.3390/ncrna8040058
ISSN: 2311-553X
Publisher: MDPI
Start Page: 58
End Page: 58
Journal / Book Title: Non-Coding RNA
Volume: 8
Issue: 4
Copyright Statement: © 2022 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https:// creativecommons.org/licenses/by/ 4.0/).
Sponsor/Funder: Ovarian Cancer Action
Funder's Grant Number: N/A
Publication Status: Published
Open Access location: https://www.mdpi.com/2311-553X/8/4/58
Article Number: ARTN 58
Appears in Collections:Materials
Department of Surgery and Cancer
Faculty of Medicine



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