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Global force-of-infection trends for human taenia solium taeniasis/cysticercosis

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Title: Global force-of-infection trends for human taenia solium taeniasis/cysticercosis
Authors: Dixon-Zegeye, M
Winskill, P
Harrison, W
Whittaker, C
Schmidt, V
Flórez Sánchez, A
Cucunubá Perez, ZM
Edia-Asuke, A
Walker, M
Basanez, M-G
Item Type: Journal Article
Abstract: Infection by Taenia solium poses a major burden across endemic countries. The World Health Organization (WHO) 2021–2030 Neglected Tropical Diseases roadmap has proposed that 30% of endemic countries achieve intensified T. solium control in hyperendemic areas by 2030. Understanding geographical variation in age-prevalence profiles and force-of-infection (FoI) estimates will inform intervention designs across settings. Human taeniasis (HTT) and human cysticercosis (HCC) age-prevalence data from 16 studies in Latin America, Africa and Asia were extracted through a systematic review. Catalytic models, incorporating diagnostic performance uncertainty, were fitted to the data using Bayesian methods, to estimate rates of antibody (Ab)-seroconversion, infection acquisition and Ab-seroreversion or infection loss. HCC FoI and Ab-seroreversion rates were also estimated across 23 departments in Colombia from 28,100 individuals. Across settings, there was extensive variation in all-ages seroprevalence. Evidence for Ab seroreversion or infection loss was found in most settings for both HTT and HCC and for HCC Ab seroreversion in Colombia. The average duration until humans became Ab-seropositive/infected decreased as all-age (sero)prevalence increased. There was no clear relationship between the average duration humans remain Ab-seropositive and all-age seroprevalence. Marked geographical heterogeneity in T. solium transmission rates indicate the need for setting43 specific intervention strategies to achieve the WHO goals.
Issue Date: 19-Aug-2022
Date of Acceptance: 8-Aug-2022
URI: http://hdl.handle.net/10044/1/98977
DOI: 10.7554/eLife.76988
ISSN: 2050-084X
Publisher: eLife Sciences Publications Ltd
Journal / Book Title: eLife
Volume: 11
Copyright Statement: © 2022, Dixon et al. This article is distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use and redistribution provided that the original author and source are credited.
Sponsor/Funder: Medical Research Council
Medical Research Council (MRC)
Funder's Grant Number: MR/K501281/1
Keywords: epidemiology
global health
neglected tropical diseases
one health
taenia solium
zoonotic infections
Bayes Theorem
Seroepidemiologic Studies
Swine Diseases
Taenia solium
Taenia solium
Swine Diseases
Bayes Theorem
Seroepidemiologic Studies
0601 Biochemistry and Cell Biology
Publication Status: Published
Article Number: ARTN e7698
Appears in Collections:Faculty of Medicine
School of Public Health

This item is licensed under a Creative Commons License Creative Commons